Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes KLHL25
  • Mouse genes Klhl25
  • Rat genes Klhl25
  • Zfish genes enc2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Klhl25

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0045182	translation regulator activity	KLHL25	IDA		Human	PMID:22578813
Molecular Function	GO:1990756	ubiquitin ligase-substrate adaptor activity	KLHL25	IDA		Human	PMID:22578813
Molecular Function	GO:1990756	ubiquitin ligase-substrate adaptor activity	KLHL25	IDA		Human	PMID:27664236
Molecular Function	GO:1990756	ubiquitin ligase-substrate adaptor activity	KLHL25	IDA		Human	PMID:34491895
Molecular Function	GO:1990756	ubiquitin ligase-substrate adaptor activity	Klhl25	IDA		Mouse	MGI:MGI:6765767|PMID:34491895
Cellular Component	GO:0031463	Cul3-RING ubiquitin ligase complex	KLHL25	IDA		Human	PMID:22578813
Cellular Component	GO:0031463	Cul3-RING ubiquitin ligase complex	KLHL25	IDA		Human	PMID:27664236
Cellular Component	GO:0031463	Cul3-RING ubiquitin ligase complex	Klhl25	IDA		Mouse	MGI:MGI:6765767|PMID:34491895
Cellular Component	GO:0005737	cytoplasm	KLHL25	IDA		Human	GO_REF:0000054
Biological Process	GO:0045717	negative regulation of fatty acid biosynthetic process	KLHL25	IDA		Human	PMID:27664236
Biological Process	GO:0032831	positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation	KLHL25	IDA		Human	PMID:34491895
Biological Process	GO:0032831	positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation	Klhl25	IDA		Mouse	MGI:MGI:6765767|PMID:34491895
Biological Process	GO:0046321	positive regulation of fatty acid oxidation	KLHL25	IDA		Human	PMID:34491895
Biological Process	GO:0046321	positive regulation of fatty acid oxidation	Klhl25	IDA		Mouse	MGI:MGI:6765767|PMID:34491895
Biological Process	GO:0016567	protein ubiquitination	KLHL25	IDA		Human	PMID:22578813
Biological Process	GO:0006446	regulation of translational initiation	KLHL25	IDA		Human	PMID:22578813
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	KLHL25	IDA		Human	PMID:22578813
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	KLHL25	IDA		Human	PMID:27664236
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	KLHL25	IDA		Human	PMID:34491895
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	Klhl25	IDA		Mouse	MGI:MGI:6765767|PMID:34491895

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern