Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes KLHDC2
  • Mouse genes Klhdc2
  • Rat genes Klhdc2
  • Zfish genes klhdc2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Klhdc2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	KLHDC2	IPI	UniProtKB:Q8IVD9	Human	PMID:25036637
Molecular Function	GO:0005515	protein binding	KLHDC2	IPI	UniProtKB:Q8IVD9	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	Klhdc2	IPI	PR:Q3UA06	Mouse	PMID:11591653
Molecular Function	GO:1990756	ubiquitin ligase-substrate adaptor activity	KLHDC2	IDA		Human	PMID:26138980
Molecular Function	GO:1990756	ubiquitin ligase-substrate adaptor activity	KLHDC2	IDA		Human	PMID:29775578
Molecular Function	GO:1990756	ubiquitin ligase-substrate adaptor activity	KLHDC2	IDA		Human	PMID:29779948
Molecular Function	GO:1990756	ubiquitin ligase-substrate adaptor activity	KLHDC2	IDA		Human	PMID:30526872
Cellular Component	GO:0031462	Cul2-RING ubiquitin ligase complex	KLHDC2	IDA		Human	PMID:26138980
Cellular Component	GO:0031462	Cul2-RING ubiquitin ligase complex	KLHDC2	IDA		Human	PMID:29775578
Cellular Component	GO:0031462	Cul2-RING ubiquitin ligase complex	KLHDC2	IDA		Human	PMID:29779948
Cellular Component	GO:0031462	Cul2-RING ubiquitin ligase complex	KLHDC2	IDA		Human	PMID:30526872
Cellular Component	GO:0016604	nuclear body	KLHDC2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0031965	nuclear membrane	KLHDC2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	KLHDC2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	KLHDC2	IDA		Human	PMID:16964437
Biological Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	KLHDC2	IDA		Human	PMID:26138980
Biological Process	GO:0140627	ubiquitin-dependent protein catabolic process via the C-end degron rule pathway	KLHDC2	IDA		Human	PMID:29775578
Biological Process	GO:0140627	ubiquitin-dependent protein catabolic process via the C-end degron rule pathway	KLHDC2	IDA		Human	PMID:29779948
Biological Process	GO:0140627	ubiquitin-dependent protein catabolic process via the C-end degron rule pathway	KLHDC2	IDA		Human	PMID:30526872

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern