Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes KHK
  • Mouse genes Khk
  • Rat genes Khk
  • Zfish genes khk
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Khk

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004454	ketohexokinase activity	KHK	IDA		Human	PMID:12941785
Molecular Function	GO:0004454	ketohexokinase activity	Khk	IDA		Mouse	PMID:29533924
Molecular Function	GO:0004454	ketohexokinase activity	Khk	IMP		Mouse	PMID:28194018
Molecular Function	GO:0004454	ketohexokinase activity	Khk	IDA		Mouse	PMID:15652177
Molecular Function	GO:0004454	ketohexokinase activity	Khk	IDA		Mouse	PMID:20841500
Molecular Function	GO:0004454	ketohexokinase activity	Khk	IDA		Mouse	PMID:22371574
Molecular Function	GO:0004454	ketohexokinase activity	Khk	IDA		Rat	PMID:8471037|RGD:633105
Molecular Function	GO:0005515	protein binding	KHK	IPI	UniProtKB:Q9NQ69	Human	PMID:25416956
Cellular Component	GO:0005737	cytoplasm	KHK	IDA		Human	GO_REF:0000054
Cellular Component	GO:0005737	cytoplasm	Khk	IDA		Mouse	PMID:19365088
Cellular Component	GO:0005737	cytoplasm	Khk	IDA		Mouse	PMID:20841500
Cellular Component	GO:0005829	cytosol	Khk	IDA		Mouse	PMID:26851500
Cellular Component	GO:0005829	cytosol	Khk	IDA		Mouse	PMID:32733884
Cellular Component	GO:0070062	extracellular exosome	KHK	HDA		Human	PMID:19056867
Cellular Component	GO:0005634	nucleus	Khk	IDA		Mouse	PMID:19365088
Cellular Component	GO:0005634	nucleus	Khk	IDA		Mouse	PMID:20841500
Biological Process	GO:0006001	fructose catabolic process	Khk	IMP	MGI:MGI:4398729	Mouse	PMID:23813872
Biological Process	GO:0006001	fructose catabolic process	Khk	IDA		Mouse	PMID:4343087
Biological Process	GO:0061624	fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate	Khk	IMP	MGI:MGI:4398729	Mouse	PMID:27465991
Biological Process	GO:0061624	fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate	Khk	IMP	MGI:MGI:4398729	Mouse	PMID:23813872
Biological Process	GO:0061624	fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate	Khk	IMP	MGI:MGI:4398729	Mouse	PMID:24022321
Biological Process	GO:0006000	fructose metabolic process	Khk	IMP	MGI:MGI:4398729	Mouse	PMID:22371574
Biological Process	GO:0006000	fructose metabolic process	Khk	IDA		Rat	PMID:8471037|RGD:633105
Biological Process	GO:0070873	regulation of glycogen metabolic process	Khk	IMP	MGI:MGI:4398729	Mouse	PMID:22371574
Biological Process	GO:0009750	response to fructose	Khk	IEP		Rat	PMID:18346472|RGD:2302251
Biological Process	GO:0009749	response to glucose	Khk	IDA		Rat	PMID:5570341|RGD:2302269
Biological Process	GO:0032868	response to insulin	Khk	IDA		Rat	PMID:6088170|RGD:2302253
Biological Process	GO:0009744	response to sucrose	Khk	IDA		Rat	PMID:6147160|RGD:2302252
Biological Process	GO:0010043	response to zinc ion	Khk	IDA		Rat	PMID:12721403|RGD:1599064

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern