Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes KDM2B
  • Mouse genes Kdm2b
  • Rat genes Kdm2b
  • Zfish genes kdm2ba,kdm2bb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Kdm2b

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0051864	histone H3K36 demethylase activity	KDM2B	IDA		Human	PMID:26237645
Molecular Function	GO:0051864	histone H3K36 demethylase activity	Kdm2b	IDA		Mouse	PMID:21540074
Molecular Function	GO:0005515	protein binding	KDM2B	IPI	UniProtKB:P63208	Human	PMID:16943429
Molecular Function	GO:0005515	protein binding	KDM2B	IPI	UniProtKB:Q6W2J9	Human	PMID:16943429
Molecular Function	GO:0005515	protein binding	KDM2B	IPI	UniProtKB:P63208	Human	PMID:24981860
Molecular Function	GO:0005515	protein binding	KDM2B	IPI	UniProtKB:Q6W2J9	Human	PMID:24981860
Molecular Function	GO:0005515	protein binding	KDM2B	IPI	UniProtKB:Q6W2J9	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	KDM2B	IPI	UniProtKB:Q6W2J9	Human	PMID:27505670
Molecular Function	GO:0005515	protein binding	KDM2B	IPI	UniProtKB:P63208	Human	PMID:27705803
Molecular Function	GO:0005515	protein binding	Kdm2b	IPI	UniProtKB:Q9CQJ4	Mouse	MGI:MGI:3715707|PMID:17296600
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Kdm2b	IDA		Mouse	PMID:21245044
Molecular Function	GO:0045322	unmethylated CpG binding	KDM2B	IDA		Human	PMID:29276034
Molecular Function	GO:0008270	zinc ion binding	KDM2B	IDA		Human	PMID:29276034
Cellular Component	GO:0005654	nucleoplasm	KDM2B	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	KDM2B	IDA		Human	PMID:26237645
Cellular Component	GO:0031519	PcG protein complex	KDM2B	IDA		Human	PMID:16943429
Biological Process	GO:0006338	chromatin remodeling	KDM2B	IDA		Human	PMID:16943429
Biological Process	GO:0048596	embryonic camera-type eye morphogenesis	Kdm2b	IMP		Mouse	MGI:MGI:4949568|PMID:21220025
Biological Process	GO:0048701	embryonic cranial skeleton morphogenesis	kdm2bb	IGI	ZFIN:ZDB-MRPHLNO-131211-1,ZFIN:ZDB-MRPHLNO-131211-4	Zfish	PMID:23920116
Biological Process	GO:0030900	forebrain development	Kdm2b	IMP		Mouse	MGI:MGI:4949568|PMID:21220025
Biological Process	GO:0021592	fourth ventricle development	Kdm2b	IMP		Mouse	MGI:MGI:4949568|PMID:21220025
Biological Process	GO:0002244	hematopoietic progenitor cell differentiation	kdm2bb	IMP		Zfish	PMID:24240475
Biological Process	GO:0030902	hindbrain development	Kdm2b	IMP		Mouse	MGI:MGI:4949568|PMID:21220025
Biological Process	GO:0021993	initiation of neural tube closure	Kdm2b	IMP		Mouse	MGI:MGI:4949568|PMID:21220025
Biological Process	GO:0021670	lateral ventricle development	Kdm2b	IMP		Mouse	MGI:MGI:4949568|PMID:21220025
Biological Process	GO:0030901	midbrain development	Kdm2b	IMP		Mouse	MGI:MGI:4949568|PMID:21220025
Biological Process	GO:0021555	midbrain-hindbrain boundary morphogenesis	Kdm2b	IMP		Mouse	MGI:MGI:4949568|PMID:21220025
Biological Process	GO:2000178	negative regulation of neural precursor cell proliferation	Kdm2b	IMP		Mouse	MGI:MGI:4949568|PMID:21220025
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	Kdm2b	IMP		Mouse	MGI:MGI:4949568|PMID:21220025
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Kdm2b	IMP		Mouse	MGI:MGI:4949568|PMID:21220025
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Kdm2b	IDA		Mouse	PMID:21540074
Biological Process	GO:0030307	positive regulation of cell growth	Kdm2b	IDA		Mouse	PMID:21540074
Biological Process	GO:1902459	positive regulation of stem cell population maintenance	Kdm2b	IDA		Mouse	PMID:21540074
Biological Process	GO:0009303	rRNA transcription	kdm2bb	IMP	ZFIN:ZDB-MRPHLNO-131211-4	Zfish	PMID:23920116
Biological Process	GO:0007283	spermatogenesis	Kdm2b	IMP		Mouse	MGI:MGI:4949568|PMID:21220025
Biological Process	GO:0021678	third ventricle development	Kdm2b	IMP		Mouse	MGI:MGI:4949568|PMID:21220025

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern