Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes KCNQ2
  • Mouse genes Kcnq2
  • Rat genes Kcnq2
  • Zfish genes kcnq2a
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Kcnq2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0030506	ankyrin binding	KCNQ2	IPI	UniProtKB:O70511	Human	PMID:16525039
Molecular Function	GO:0005516	calmodulin binding	KCNQ2	IDA		Human	PMID:27564677
Molecular Function	GO:0005516	calmodulin binding	Kcnq2	IPI	PR:Q9Z351	Mouse	PMID:12223552
Molecular Function	GO:0005515	protein binding	KCNQ2	IPI	UniProtKB:P0DP23	Human	PMID:27564677
Molecular Function	GO:0005515	protein binding	KCNQ2	IPI	UniProtKB:P53794	Human	PMID:28793216
Molecular Function	GO:0005515	protein binding	Kcnq2	IPI	UniProtKB:A0A088MLT8	Mouse	MGI:MGI:5888972|PMID:27979964
Molecular Function	GO:0005515	protein binding	Kcnq2	IPI	RGD:620829	Rat	PMID:12754513|RGD:632236
Molecular Function	GO:0005244	voltage-gated monoatomic ion channel activity	Kcnq2	IGI	MGI:MGI:1336181	Mouse	PMID:12223552
Molecular Function	GO:0005249	voltage-gated potassium channel activity	KCNQ2	IDA		Human	PMID:27564677
Molecular Function	GO:0005249	voltage-gated potassium channel activity	KCNQ2	IDA		Human	PMID:9836639
Molecular Function	GO:0005249	voltage-gated potassium channel activity	Kcnq2	IDA		Rat	PMID:11038262|RGD:12910995
Molecular Function	GO:0005249	voltage-gated potassium channel activity	Kcnq2	IDA		Rat	PMID:11230508|RGD:12910989
Cellular Component	GO:0043194	axon initial segment	Kcnq2	IDA		Mouse	MGI:MGI:3617955|PMID:16525039
Cellular Component	GO:0043194	axon initial segment	Kcnq2	IDA		Rat	PMID:17311847|RGD:153344585
Cellular Component	GO:0009986	cell surface	Kcnq2	IDA		Mouse	PMID:12223552
Cellular Component	GO:0033268	node of Ranvier	Kcnq2	IDA		Mouse	MGI:MGI:3617955|PMID:16525039
Cellular Component	GO:0005886	plasma membrane	KCNQ2	IDA		Human	PMID:10788442
Cellular Component	GO:0005886	plasma membrane	KCNQ2	IDA		Human	PMID:9836639
Cellular Component	GO:0005886	plasma membrane	Kcnq2	IDA		Mouse	MGI:MGI:3617955|PMID:16525039
Cellular Component	GO:0005886	plasma membrane	Kcnq2	IDA		Rat	PMID:11038262|RGD:12910995
Cellular Component	GO:0005886	plasma membrane	Kcnq2	IDA		Rat	PMID:11230508|RGD:12910989
Cellular Component	GO:0008076	voltage-gated potassium channel complex	KCNQ2	IDA		Human	PMID:27564677
Cellular Component	GO:0008076	voltage-gated potassium channel complex	KCNQ2	IDA		Human	PMID:9836639
Cellular Component	GO:0008076	voltage-gated potassium channel complex	Kcnq2	IGI	MGI:MGI:1336181	Mouse	PMID:12223552
Cellular Component	GO:0008076	voltage-gated potassium channel complex	Kcnq2	IDA		Rat	PMID:11230508|RGD:12910989
Biological Process	GO:0060081	membrane hyperpolarization	Kcnq2	IMP	MGI:MGI:3604594	Mouse	MGI:MGI:62459
Biological Process	GO:0071805	potassium ion transmembrane transport	KCNQ2	IDA		Human	PMID:27564677
Biological Process	GO:0071805	potassium ion transmembrane transport	KCNQ2	IDA		Human	PMID:9836639
Biological Process	GO:0071805	potassium ion transmembrane transport	Kcnq2	IDA		Rat	PMID:11038262|RGD:12910995
Biological Process	GO:0071805	potassium ion transmembrane transport	Kcnq2	IDA		Rat	PMID:11230508|RGD:12910989
Biological Process	GO:0019226	transmission of nerve impulse	Kcnq2	IMP	MGI:MGI:2386963	Mouse	PMID:10854243

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern