Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes KANK1
  • Mouse genes Kank1
  • Rat genes Kank1
  • Zfish genes kank1a
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Kank1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008013	beta-catenin binding	KANK1	IDA		Human	PMID:16968744
Molecular Function	GO:0005515	protein binding	KANK1	IPI	UniProtKB:P35222	Human	PMID:16968744
Molecular Function	GO:0005515	protein binding	KANK1	IPI	UniProtKB:P27348	Human	PMID:18458160
Molecular Function	GO:0005515	protein binding	KANK1	IPI	UniProtKB:Q9UQB8	Human	PMID:19171758
Molecular Function	GO:0005515	protein binding	KANK1	IPI	UniProtKB:P27348	Human	PMID:19559006
Molecular Function	GO:0005515	protein binding	KANK1	IPI	UniProtKB:Q7Z4S6	Human	PMID:19559006
Molecular Function	GO:0005515	protein binding	KANK1	IPI	UniProtKB:Q7Z4S6	Human	PMID:22084092
Molecular Function	GO:0005515	protein binding	KANK1	IPI	UniProtKB:Q9Y6D6	Human	PMID:22084092
Molecular Function	GO:0005515	protein binding	KANK1	IPI	UniProtKB:Q7Z4S6	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	KANK1	IPI	UniProtKB:Q7Z4S6	Human	PMID:29183992
Cellular Component	GO:0005737	cytoplasm	KANK1	IDA		Human	PMID:12133830
Cellular Component	GO:0005886	plasma membrane	KANK1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0032587	ruffle membrane	KANK1	IDA		Human	PMID:19559006
Biological Process	GO:0030036	actin cytoskeleton organization	KANK1	IMP		Human	PMID:12133830
Biological Process	GO:0008283	cell population proliferation	KANK1	IMP		Human	PMID:12133830
Biological Process	GO:0030837	negative regulation of actin filament polymerization	KANK1	IDA		Human	PMID:17996375
Biological Process	GO:0030837	negative regulation of actin filament polymerization	KANK1	IDA		Human	PMID:18458160
Biological Process	GO:0030336	negative regulation of cell migration	KANK1	IMP		Human	PMID:18458160
Biological Process	GO:0046627	negative regulation of insulin receptor signaling pathway	KANK1	IMP		Human	PMID:18458160
Biological Process	GO:2000393	negative regulation of lamellipodium morphogenesis	KANK1	IDA		Human	PMID:19171758
Biological Process	GO:0010977	negative regulation of neuron projection development	KANK1	IDA		Human	PMID:19171758
Biological Process	GO:0035024	negative regulation of Rho protein signal transduction	KANK1	IMP		Human	PMID:18458160
Biological Process	GO:1900028	negative regulation of ruffle assembly	KANK1	IDA		Human	PMID:19171758
Biological Process	GO:1900025	negative regulation of substrate adhesion-dependent cell spreading	KANK1	IDA		Human	PMID:19171758
Biological Process	GO:0090521	podocyte cell migration	KANK1	IMP		Human	PMID:25961457
Biological Process	GO:0090263	positive regulation of canonical Wnt signaling pathway	KANK1	IMP		Human	PMID:16968744
Biological Process	GO:0030177	positive regulation of Wnt signaling pathway	KANK1	IDA		Human	PMID:16968744
Biological Process	GO:0090303	positive regulation of wound healing	KANK1	IMP		Human	PMID:22084092
Biological Process	GO:2000114	regulation of establishment of cell polarity	KANK1	IMP		Human	PMID:22084092
Biological Process	GO:0035023	regulation of Rho protein signal transduction	KANK1	IMP		Human	PMID:25961457

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern