Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ITM2C
  • Mouse genes Itm2c
  • Rat genes Itm2c
  • Zfish genes itm2ca,itm2cb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Itm2c

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001540	amyloid-beta binding	ITM2C	IPI	UniProtKB:P05067	Human	PMID:19849849
Molecular Function	GO:0005524	ATP binding	Itm2c	IDA		Mouse	PMID:10679242
Molecular Function	GO:0005515	protein binding	ITM2C	IPI	UniProtKB:Q93045	Human	PMID:18452648
Molecular Function	GO:0005515	protein binding	ITM2C	IPI	UniProtKB:P05067:PRO_0000000091	Human	PMID:19366692
Cellular Component	GO:0070062	extracellular exosome	ITM2C	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	ITM2C	HDA		Human	PMID:19199708
Cellular Component	GO:0005794	Golgi apparatus	ITM2C	IDA		Human	GO_REF:0000054
Cellular Component	GO:0005764	lysosome	ITM2C	IDA		Human	PMID:14592447
Cellular Component	GO:0005764	lysosome	Itm2c	IDA		Mouse	MGI:MGI:4821078|PMID:14592447
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ITM2C	IDA		Human	PMID:18452648
Cellular Component	GO:0005886	plasma membrane	ITM2C	IDA		Human	PMID:19114711
Biological Process	GO:0010977	negative regulation of neuron projection development	ITM2C	IDA		Human	PMID:18452648
Biological Process	GO:0030182	neuron differentiation	ITM2C	IDA		Human	PMID:18452648
Biological Process	GO:2001238	positive regulation of extrinsic apoptotic signaling pathway	Itm2c	IMP		Mouse	MGI:MGI:4821078|PMID:14592447

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern