Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ITGAX
  • Mouse genes Itgax
  • Rat genes Itgax
  • Zfish genes itgam.1,itgam.2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Itgax

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	ITGAX	IPI	UniProtKB:Q5JRA6	Human	PMID:17726152
Molecular Function	GO:0005515	protein binding	ITGAX	IPI	UniProtKB:P05107	Human	PMID:20033057
Molecular Function	GO:0005515	protein binding	ITGAX	IPI	UniProtKB:P05107	Human	PMID:20679211
Molecular Function	GO:0030971	receptor tyrosine kinase binding	ITGAX	IPI	UniProtKB:P35968	Human	PMID:30873824
Cellular Component	GO:0009986	cell surface	ITGAX	IDA		Human	PMID:19234460
Cellular Component	GO:0009986	cell surface	ITGAX	HDA		Human	PMID:23981064
Cellular Component	GO:0009897	external side of plasma membrane	Itgax	IDA		Mouse	PMID:18984740
Cellular Component	GO:0009897	external side of plasma membrane	Itgax	IDA		Mouse	PMID:1385153
Cellular Component	GO:0009897	external side of plasma membrane	Itgax	IDA		Mouse	PMID:10648399
Cellular Component	GO:0009897	external side of plasma membrane	Itgax	IDA		Mouse	PMID:19723499
Cellular Component	GO:0009897	external side of plasma membrane	Itgax	IDA		Mouse	PMID:12801066
Cellular Component	GO:0009897	external side of plasma membrane	Itgax	IDA		Mouse	PMID:14643301
Cellular Component	GO:0009897	external side of plasma membrane	Itgax	IDA		Mouse	PMID:14990792
Cellular Component	GO:0009897	external side of plasma membrane	Itgax	IDA		Mouse	PMID:17277142
Cellular Component	GO:0009897	external side of plasma membrane	Itgax	IDA		Mouse	PMID:14609575
Cellular Component	GO:0016020	membrane	ITGAX	HDA		Human	PMID:19946888
Biological Process	GO:0051607	defense response to virus	Itgax	IDA		Mouse	PMID:17277142
Biological Process	GO:0034113	heterotypic cell-cell adhesion	ITGAX	IMP		Human	PMID:20563599
Biological Process	GO:0045766	positive regulation of angiogenesis	ITGAX	IMP		Human	PMID:30873824
Biological Process	GO:0030335	positive regulation of cell migration	ITGAX	IMP		Human	PMID:30873824
Biological Process	GO:0008284	positive regulation of cell population proliferation	ITGAX	IMP		Human	PMID:30873824
Biological Process	GO:1905956	positive regulation of endothelial tube morphogenesis	ITGAX	IMP		Human	PMID:30873824
Biological Process	GO:0010628	positive regulation of gene expression	ITGAX	IMP		Human	PMID:30873824
Biological Process	GO:0010628	positive regulation of gene expression	Itgax	IDA		Mouse	MGI:MGI:6094573|PMID:28963396
Biological Process	GO:0031643	positive regulation of myelination	Itgax	IDA		Mouse	MGI:MGI:6094573|PMID:28963396

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern