Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes IRX6
  • Mouse genes Irx6
  • Rat genes Irx6
  • Zfish genes irx6a
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Irx6

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Irx6	IDA		Mouse	PMID:23172916
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	Irx6	IDA		Mouse	PMID:23172916
Molecular Function	GO:0005515	protein binding	IRX6	IPI	UniProtKB:O43186	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IRX6	IPI	UniProtKB:O60806	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IRX6	IPI	UniProtKB:O76003	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IRX6	IPI	UniProtKB:P10916	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IRX6	IPI	UniProtKB:P49639	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IRX6	IPI	UniProtKB:Q03989	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IRX6	IPI	UniProtKB:Q08117-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IRX6	IPI	UniProtKB:Q3SYF9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IRX6	IPI	UniProtKB:Q6FHY5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IRX6	IPI	UniProtKB:Q8NI38	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IRX6	IPI	UniProtKB:Q96RU7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IRX6	IPI	UniProtKB:Q99471	Human	PMID:32296183
Biological Process	GO:0009584	detection of visible light	Irx6	IMP	MGI:MGI:5448232	Mouse	PMID:23172916
Biological Process	GO:0006351	DNA-templated transcription	Irx6	IDA		Mouse	MGI:MGI:5447580|PMID:23172916
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Irx6	IDA		Mouse	PMID:23172916
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Irx6	IDA		Mouse	MGI:MGI:5447580|PMID:23172916
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Irx6	IDA		Mouse	PMID:23172916
Biological Process	GO:0010842	retina layer formation	Irx6	IMP	MGI:MGI:5448232	Mouse	PMID:23172916
Biological Process	GO:0060040	retinal bipolar neuron differentiation	Irx6	IMP	MGI:MGI:5448232	Mouse	PMID:23172916

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern