Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes IP6K2
  • Mouse genes Ip6k2
  • Rat genes Ip6k2
  • Zfish genes ip6k2a,ip6k2b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ip6k2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0097243	flavonoid binding	IP6K2	IDA		Human	PMID:30624931
Molecular Function	GO:0000832	inositol hexakisphosphate 5-kinase activity	IP6K2	IDA		Human	PMID:30624931
Molecular Function	GO:0000828	inositol hexakisphosphate kinase activity	IP6K2	IDA		Human	PMID:10574768
Molecular Function	GO:0000828	inositol hexakisphosphate kinase activity	Ip6k2	IMP	MGI:MGI:5635272	Mouse	PMID:24657168
Molecular Function	GO:0005515	protein binding	IP6K2	IPI	UniProtKB:P07900	Human	PMID:18195352
Molecular Function	GO:0005515	protein binding	IP6K2	IPI	UniProtKB:P04637	Human	PMID:21078964
Molecular Function	GO:0005515	protein binding	IP6K2	IPI	UniProtKB:Q8N448	Human	PMID:21516116
Molecular Function	GO:0005515	protein binding	IP6K2	IPI	UniProtKB:P50222	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	IP6K2	IPI	UniProtKB:Q93062	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	IP6K2	IPI	UniProtKB:Q8N448	Human	PMID:29892012
Molecular Function	GO:0005515	protein binding	IP6K2	IPI	UniProtKB:Q8N448	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	IP6K2	IPI	UniProtKB:O60568	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IP6K2	IPI	UniProtKB:Q8N680	Human	PMID:32296183
Cellular Component	GO:0030054	cell junction	IP6K2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0001650	fibrillar center	IP6K2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	IP6K2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	IP6K2	IDA		Human	PMID:11502751
Cellular Component	GO:0005634	nucleus	Ip6k2	IDA		Mouse	MGI:MGI:3688053|PMID:11502751
Biological Process	GO:1905396	cellular response to flavonoid	IP6K2	IMP		Human	PMID:30624931
Biological Process	GO:0032958	inositol phosphate biosynthetic process	Ip6k2	IMP	MGI:MGI:5635272	Mouse	PMID:24657168
Biological Process	GO:0043647	inositol phosphate metabolic process	IP6K2	IDA		Human	PMID:30624931
Biological Process	GO:0030308	negative regulation of cell growth	IP6K2	IMP		Human	PMID:11337497
Biological Process	GO:0006817	phosphate ion transport	Ip6k2	IDA		Rat	PMID:10527952|RGD:633655
Biological Process	GO:0046854	phosphatidylinositol phosphate biosynthetic process	IP6K2	IDA		Human	PMID:10574768
Biological Process	GO:0043065	positive regulation of apoptotic process	IP6K2	IMP		Human	PMID:11337497
Biological Process	GO:0033138	positive regulation of peptidyl-serine phosphorylation	Ip6k2	IMP	MGI:MGI:5635272	Mouse	PMID:24657168
Biological Process	GO:0045880	positive regulation of smoothened signaling pathway	ip6k2a	IMP	ZFIN:ZDB-MRPHLNO-101201-4	Zfish	PMID:20980661
Biological Process	GO:0045880	positive regulation of smoothened signaling pathway	ip6k2a	IMP	ZFIN:ZDB-MRPHLNO-101201-2,ZFIN:ZDB-MRPHLNO-101201-3	Zfish	PMID:20980661
Biological Process	GO:0050821	protein stabilization	Ip6k2	IMP	MGI:MGI:5635272	Mouse	PMID:24657168
Biological Process	GO:0007227	signal transduction downstream of smoothened	ip6k2a	IMP	ZFIN:ZDB-MRPHLNO-101201-4	Zfish	PMID:20980661
Biological Process	GO:0007227	signal transduction downstream of smoothened	ip6k2a	IMP	ZFIN:ZDB-MRPHLNO-101201-2,ZFIN:ZDB-MRPHLNO-101201-3	Zfish	PMID:20980661

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern