Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes IMPDH2
  • Mouse genes Impdh2
  • Rat genes Impdh2
  • Zfish genes impdh2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Impdh2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042802	identical protein binding	Impdh2	IPI	RGD:735092	Rat	PMID:2897864|RGD:5147398
Molecular Function	GO:0003938	IMP dehydrogenase activity	IMPDH2	IDA		Human	PMID:7903306
Molecular Function	GO:0003938	IMP dehydrogenase activity	Impdh2	IDA		Mouse	PMID:12944494
Molecular Function	GO:0003938	IMP dehydrogenase activity	Impdh2	IDA		Mouse	PMID:1671845
Molecular Function	GO:0003938	IMP dehydrogenase activity	Impdh2	IMP		Mouse	PMID:12944494
Molecular Function	GO:0003938	IMP dehydrogenase activity	Impdh2	IDA		Rat	PMID:2897864|RGD:5147398
Molecular Function	GO:0000166	nucleotide binding	IMPDH2	IDA		Human	PMID:14766016
Molecular Function	GO:0005515	protein binding	IMPDH2	IPI	UniProtKB:Q96GX9	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	IMPDH2	IPI	UniProtKB:Q9BU20	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	IMPDH2	IPI	UniProtKB:O15516	Human	PMID:28985504
Molecular Function	GO:0005515	protein binding	IMPDH2	IPI	UniProtKB:O95994	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IMPDH2	IPI	UniProtKB:P20839-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IMPDH2	IPI	UniProtKB:P40763	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IMPDH2	IPI	UniProtKB:P78424	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IMPDH2	IPI	UniProtKB:Q12933	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IMPDH2	IPI	UniProtKB:Q8WWZ1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IMPDH2	IPI	UniProtKB:Q9BU20	Human	PMID:32296183
Cellular Component	GO:0005737	cytoplasm	IMPDH2	IDA		Human	PMID:14766016
Cellular Component	GO:0005829	cytosol	IMPDH2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	IMPDH2	IDA		Human	PMID:31337707
Cellular Component	GO:0070062	extracellular exosome	IMPDH2	HDA		Human	PMID:20458337
Cellular Component	GO:0016020	membrane	IMPDH2	HDA		Human	PMID:19946888
Cellular Component	GO:0005634	nucleus	IMPDH2	IDA		Human	PMID:14766016
Cellular Component	GO:0005778	peroxisomal membrane	IMPDH2	HDA		Human	PMID:21525035
Biological Process	GO:0097294	'de novo' XMP biosynthetic process	Impdh2	IMP	MGI:MGI:2678388	Mouse	PMID:12944494
Biological Process	GO:0071353	cellular response to interleukin-4	Impdh2	IDA		Mouse	PMID:9798653
Biological Process	GO:0007623	circadian rhythm	IMPDH2	IDA		Human	PMID:28985504
Biological Process	GO:0007623	circadian rhythm	impdh2	IMP	ZFIN:ZDB-MRPHLNO-150519-3	Zfish	PMID:25714999
Biological Process	GO:0006177	GMP biosynthetic process	Impdh2	IDA		Mouse	PMID:1671845
Biological Process	GO:0006177	GMP biosynthetic process	Impdh2	IMP	MGI:MGI:2678388	Mouse	PMID:12944494
Biological Process	GO:0006183	GTP biosynthetic process	IMPDH2	IDA		Human	PMID:7903306
Biological Process	GO:0046651	lymphocyte proliferation	Impdh2	IMP	MGI:MGI:2678388	Mouse	PMID:12944494
Biological Process	GO:0006164	purine nucleotide biosynthetic process	Impdh2	IMP	MGI:MGI:2678388	Mouse	PMID:12944494
Biological Process	GO:0006164	purine nucleotide biosynthetic process	Impdh2	IDA		Rat	PMID:2897864|RGD:5147398
Biological Process	GO:0060041	retina development in camera-type eye	Impdh2	IEP		Rat	PMID:18295529|RGD:5144133

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern