Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes IL18R1
  • Mouse genes Il18r1
  • Rat genes Il18r1
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Il18r1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042007	interleukin-18 binding	IL18R1	IDA		Human	PMID:14528293
Molecular Function	GO:0042007	interleukin-18 binding	IL18R1	IDA		Human	PMID:25261253
Molecular Function	GO:0042007	interleukin-18 binding	IL18R1	IDA		Human	PMID:25500532
Molecular Function	GO:0042008	interleukin-18 receptor activity	IL18R1	IDA		Human	PMID:25500532
Molecular Function	GO:0042008	interleukin-18 receptor activity	Il18r1	IMP	MGI:MGI:2136765	Mouse	PMID:10227969
Molecular Function	GO:0005515	protein binding	IL18R1	IPI	UniProtKB:Q14116	Human	PMID:25261253
Molecular Function	GO:0005515	protein binding	Il18r1	IPI	UniProtKB:P59158	Mouse	MGI:MGI:5689220|PMID:26099046
Cellular Component	GO:0045092	interleukin-18 receptor complex	IL18R1	IDA		Human	PMID:25500532
Biological Process	GO:0035655	interleukin-18-mediated signaling pathway	IL18R1	IDA		Human	PMID:25500532
Biological Process	GO:0035655	interleukin-18-mediated signaling pathway	Il18r1	IMP	MGI:MGI:2136765	Mouse	PMID:10227969
Biological Process	GO:0030101	natural killer cell activation	Il18r1	IMP	MGI:MGI:2136765	Mouse	PMID:10227969
Biological Process	GO:0120163	negative regulation of cold-induced thermogenesis	Il18r1	IMP		Mouse	MGI:MGI:6101026|PMID:26656097
Biological Process	GO:0038061	NIK/NF-kappaB signaling	Il18r1	IMP	MGI:MGI:2136765	Mouse	PMID:10227969
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	IL18R1	IDA		Human	PMID:25500532
Biological Process	GO:1901224	positive regulation of NIK/NF-kappaB signaling	Il18r1	IMP	MGI:MGI:2136765	Mouse	PMID:10227969
Biological Process	GO:2000556	positive regulation of T-helper 1 cell cytokine production	IL18R1	IDA		Human	PMID:10653850
Biological Process	GO:0032729	positive regulation of type II interferon production	IL18R1	IDA		Human	PMID:10653850
Biological Process	GO:0032729	positive regulation of type II interferon production	Il18r1	IMP	MGI:MGI:2136765	Mouse	PMID:10227969
Biological Process	GO:0045063	T-helper 1 cell differentiation	Il18r1	IMP	MGI:MGI:2136765	Mouse	PMID:10227969
Biological Process	GO:0032609	type II interferon production	Il18r1	IMP	MGI:MGI:2136765	Mouse	PMID:10227969

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern