Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes IL12RB1
  • Mouse genes Il12rb1
  • Rat genes Il12rb1
  • Zfish genes il12rb1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Il12rb1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0019955	cytokine binding	Il12rb1	IPI	UniProtKB:P43432|UniProtKB:Q9EQ14	Mouse	MGI:MGI:1927676|PMID:11114383
Molecular Function	GO:0016517	interleukin-12 receptor activity	IL12RB1	IDA		Human	PMID:8943050
Molecular Function	GO:0005143	interleukin-12 receptor binding	IL12RB1	IPI	UniProtKB:Q99665	Human	PMID:12023369
Molecular Function	GO:0042019	interleukin-23 binding	IL12RB1	IPI	UniProtKB:Q9NPF7	Human	PMID:12023369
Molecular Function	GO:0042020	interleukin-23 receptor activity	IL12RB1	IDA		Human	PMID:12023369
Cellular Component	GO:0009897	external side of plasma membrane	Il12rb1	IDA		Mouse	PMID:15220916
Cellular Component	GO:0042022	interleukin-12 receptor complex	IL12RB1	IDA		Human	PMID:12023369
Cellular Component	GO:0072536	interleukin-23 receptor complex	IL12RB1	IDA		Human	PMID:12023369
Cellular Component	GO:0072536	interleukin-23 receptor complex	Il12rb1	IDA		Mouse	MGI:MGI:1927676|PMID:11114383
Biological Process	GO:0071346	cellular response to type II interferon	IL12RB1	IDA		Human	PMID:12023369
Biological Process	GO:0035722	interleukin-12-mediated signaling pathway	IL12RB1	IDA		Human	PMID:8943050
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	Il12rb1	IMP		Mouse	PMID:11489994
Biological Process	GO:0042104	positive regulation of activated T cell proliferation	IL12RB1	IDA		Human	PMID:11114383
Biological Process	GO:0002230	positive regulation of defense response to virus by host	IL12RB1	IDA		Human	PMID:12421946
Biological Process	GO:0042102	positive regulation of T cell proliferation	Il12rb1	IDA		Mouse	MGI:MGI:1927676|PMID:11114383
Biological Process	GO:0002827	positive regulation of T-helper 1 type immune response	IL12RB1	IDA		Human	PMID:15114670
Biological Process	GO:0032729	positive regulation of type II interferon production	IL12RB1	IDA		Human	PMID:11114383
Biological Process	GO:0032729	positive regulation of type II interferon production	IL12RB1	IMP		Human	PMID:14635048

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern