Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes IER2
  • Mouse genes Ier2
  • Rat genes Ier2
  • Zfish genes ier2a,ier2b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ier2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	IER2	IPI	UniProtKB:O75031	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IER2	IPI	UniProtKB:O94817	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ier2a	IPI	UniProtKB:Q6T938	Zfish	PMID:19164561
Cellular Component	GO:0005737	cytoplasm	IER2	IDA		Human	PMID:22120713
Cellular Component	GO:0005737	cytoplasm	Ier2	IDA		Mouse	PMID:2247083
Cellular Component	GO:0005654	nucleoplasm	IER2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	IER2	IDA		Human	PMID:22120713
Cellular Component	GO:0005634	nucleus	ier2a	IGI	ZFIN:ZDB-GENE-040630-2	Zfish	PMID:19164561
Biological Process	GO:0048870	cell motility	IER2	IMP		Human	PMID:22120713
Biological Process	GO:0060271	cilium assembly	ier2a	IMP	ZFIN:ZDB-MRPHLNO-091020-10	Zfish	PMID:19164561
Biological Process	GO:0060271	cilium assembly	ier2a	IGI	ZFIN:ZDB-MRPHLNO-091020-10,ZFIN:ZDB-MRPHLNO-091020-11	Zfish	PMID:19164561
Biological Process	GO:0060026	convergent extension	ier2a	IMP	ZFIN:ZDB-MRPHLNO-091020-10	Zfish	PMID:19164561
Biological Process	GO:0007368	determination of left/right symmetry	ier2a	IGI	ZFIN:ZDB-MRPHLNO-091020-10,ZFIN:ZDB-MRPHLNO-091020-11	Zfish	PMID:19164561
Biological Process	GO:0007368	determination of left/right symmetry	ier2a	IMP	ZFIN:ZDB-MRPHLNO-091020-10	Zfish	PMID:19164561
Biological Process	GO:0070121	Kupffer's vesicle development	ier2a	IGI	ZFIN:ZDB-MRPHLNO-091020-10,ZFIN:ZDB-MRPHLNO-091020-11	Zfish	PMID:19164561
Biological Process	GO:0070121	Kupffer's vesicle development	ier2a	IMP	ZFIN:ZDB-MRPHLNO-091020-10	Zfish	PMID:19164561
Biological Process	GO:0030182	neuron differentiation	Ier2	IDA		Rat	PMID:17156131|RGD:10054080
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IER2	IDA		Human	PMID:19584537
Biological Process	GO:0071774	response to fibroblast growth factor	Ier2	IDA		Rat	PMID:17156131|RGD:10054080

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern