Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes IDH2
  • Mouse genes Idh2
  • Rat genes Idh2
  • Zfish genes idh2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Idh2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004450	isocitrate dehydrogenase (NADP+) activity	IDH2	IMP		Human	PMID:22416140
Molecular Function	GO:0004450	isocitrate dehydrogenase (NADP+) activity	IDH2	IDA		Human	PMID:23226729
Molecular Function	GO:0004450	isocitrate dehydrogenase (NADP+) activity	Idh2	IDA		Mouse	PMID:18275837
Molecular Function	GO:0004450	isocitrate dehydrogenase (NADP+) activity	Idh2	IDA		Mouse	PMID:8867815
Molecular Function	GO:0004450	isocitrate dehydrogenase (NADP+) activity	Idh2	IDA		Mouse	PMID:7323947
Molecular Function	GO:0004450	isocitrate dehydrogenase (NADP+) activity	Idh2	IDA		Rat	PMID:9354646|RGD:11522739
Cellular Component	GO:0005829	cytosol	Idh2	IDA		Mouse	PMID:18275837
Cellular Component	GO:0070062	extracellular exosome	IDH2	HDA		Human	PMID:23533145
Cellular Component	GO:0005743	mitochondrial inner membrane	Idh2	HDA		Mouse	PMID:12865426
Cellular Component	GO:0005739	mitochondrion	IDH2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005739	mitochondrion	IDH2	HDA		Human	PMID:20833797
Cellular Component	GO:0005739	mitochondrion	Idh2	HDA		Mouse	PMID:14651853
Cellular Component	GO:0005739	mitochondrion	Idh2	HDA		Mouse	PMID:18614015
Cellular Component	GO:0005777	peroxisome	Idh2	IDA		Mouse	PMID:18275837
Biological Process	GO:0006741	NADP biosynthetic process	Idh2	IMP		Rat	PMID:21641335|RGD:11522736
Biological Process	GO:1903976	negative regulation of glial cell migration	Idh2	IMP		Rat	PMID:22105553|RGD:11522738
Biological Process	GO:0060253	negative regulation of glial cell proliferation	Idh2	IMP		Rat	PMID:21641335|RGD:11522736
Biological Process	GO:1904465	negative regulation of matrix metallopeptidase secretion	Idh2	IMP		Rat	PMID:22105553|RGD:11522738

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern