Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ICOS
  • Mouse genes Icos
  • Rat genes Icos
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Icos

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	ICOS	IPI	UniProtKB:O75144	Human	PMID:11956294
Molecular Function	GO:0005515	protein binding	ICOS	IPI	UniProtKB:O75144	Human	PMID:16951355
Molecular Function	GO:0005515	protein binding	ICOS	IPI	UniProtKB:P27986	Human	PMID:18641334
Molecular Function	GO:0005515	protein binding	ICOS	IPI	UniProtKB:P27986	Human	PMID:27135603
Molecular Function	GO:0005515	protein binding	ICOS	IPI	UniProtKB:Q9UHD2	Human	PMID:27135603
Molecular Function	GO:0005515	protein binding	Icos	IPI	UniProtKB:P26450	Mouse	MGI:MGI:6120056|PMID:27135603
Molecular Function	GO:0005515	protein binding	Icos	IPI	PR:Q9JHJ8	Mouse	PMID:10657606
Molecular Function	GO:0005515	protein binding	Icos	IPI	PR:Q9JHJ8	Mouse	PMID:10760791
Cellular Component	GO:0009897	external side of plasma membrane	Icos	IDA		Mouse	PMID:16227984
Cellular Component	GO:0009897	external side of plasma membrane	Icos	IDA		Mouse	PMID:19008373
Cellular Component	GO:0009897	external side of plasma membrane	Icos	IDA		Mouse	PMID:10760791
Cellular Component	GO:0009897	external side of plasma membrane	Icos	IDA		Mouse	PMID:23583643
Cellular Component	GO:0005886	plasma membrane	Icos	IDA		Mouse	PMID:10760791
Biological Process	GO:0098609	cell-cell adhesion	Icos	IDA		Rat	PMID:10607749|RGD:1624277
Biological Process	GO:0031295	T cell costimulation	Icos	IDA		Rat	PMID:11006126|RGD:631942
Biological Process	GO:0002517	T cell tolerance induction	Icos	IMP		Rat	PMID:16220623|RGD:1624271

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern