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Icos
Gene Detail
 Symbol
Name
ID
Icos
inducible T cell co-stimulator
MGI:1858745
Feature Type protein coding gene
Genetic Map
Chromosome 1
30.60 cM
Detailed Genetic Map ± 1 cM


Mapping data(9)
Sequence Map
Chr1:60977927-61000320 bp, + strand
From VEGA annotation of GRCm38

  22394 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8097  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: T-cell surface glycoprotein CD28
Gene Tree: Icos

Human
homologs
Human Homolog ICOS, inducible T-cell co-stimulator
NCBI Gene ID 29851
neXtProt AC  NX_Q9Y6W8
Human Synonyms  AILIM, CD278, CVID1
Human Chr (Location)  2q33; chr2:203936731-203961579 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human ICOS
Alleles
and
phenotypes
All alleles(14) : Targeted(14)
 
Mice homozygous for disruptions in this gene show reduced basal IgG1 levels and impaired interactions between T and B cells. T cell dependent B cell isotype switching was impaired as well.
 
Human Diseases Modeled Using Mouse Icos (1)    Alleles Annotated to Human Diseases(2)   
Gene Ontology
(GO)
classifications
All GO classifications: (5 annotations)
Component external side of plasma membrane, integral component of membrane, ...
Function protein binding
External Resources: FuncBase
Expression
cDNA source data(42)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(43) cDNA(42) Primer pair(1)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000002307 (Evidence)
Ensembl Gene ModelENSMUSG00000026009 (Evidence)
Entrez Gene54167 (Evidence)
UniGene42044
DFCITC1583048, TC1634706, TC1641189
DoTSDT.487967, DT.528748
NIA Mouse Gene IndexU042165
Consensus CDS ProjectCCDS14994.1
International Mouse Knockout Project StatusIcos
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000002307 VEGA Gene Model | MGI Sequence Detail 22394 C57BL/6J ±  kb
transcript OTTMUST00000004596 VEGA | MGI Sequence Detail 810 Not Applicable 
polypeptide OTTMUSP00000002207 VEGA | MGI Sequence Detail 223 Not Applicable 

For the selected sequences
All sequences(45) RefSeq(12) UniProt(4)
Polymorphisms PCR(1) : SNPs within 2kb(145 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
Protein Ontology PR:000001860 inducible T-cell costimulator
References (Earliest) J:60318 Ling V, et al., Cutting edge: identification of GL50, a novel B7-like protein that functionally binds to ICOS receptor. J Immunol. 2000 Feb 15;164(4):1653-7
(Latest) J:205790 Colino J, et al., Noncovalent association of protein and capsular polysaccharide on bacteria-sized latex beads as a model for polysaccharide-specific humoral immunity to intact gram-positive extracellular bacteria. J Immunol. 2013 Sep 15;191(6):3254-63
All references(114)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory