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Icos Gene Detail
Summary
  • Symbol
    Icos
  • Name
    inducible T cell co-stimulator
  • Feature Type
    protein coding gene
  • IDs
    MGI:1858745
    NCBI Gene: 54167
  • Gene Overview
    MyGene.info: ICOS
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:60977927-61000320 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 30.60 cM
  • Mapping Data
    9 experiments
Strain
Comparison
more
  • SNPs within 2kb
    222 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1858745
protein coding gene Chr1:60960773-61000322 (.)
129S1/SvImJ MGP_129S1SvImJ_G0016081
protein coding gene Chr1:61060949-61083480 (+)
A/J MGP_AJ_G0016064
protein coding gene Chr1:58894833-58918414 (+)
AKR/J MGP_AKRJ_G0016020
protein coding gene Chr1:60570446-60593453 (+)
BALB/cJ MGP_BALBcJ_G0016019
protein coding gene Chr1:58944642-58966284 (+)
C3H/HeJ MGP_C3HHeJ_G0015851
protein coding gene Chr1:60800328-60822810 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016472
protein coding gene Chr1:63447502-63468881 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014193
protein coding gene Chr1:55095458-55120153 (+)
CAST/EiJ MGP_CASTEiJ_G0015433
protein coding gene Chr1:60009151-60039934 (+)
CBA/J MGP_CBAJ_G0015823
protein coding gene Chr1:65443193-65466338 (+)
DBA/2J MGP_DBA2J_G0015924
protein coding gene Chr1:58331480-58353147 (+)
FVB/NJ MGP_FVBNJ_G0015926
protein coding gene Chr1:57622118-57643474 (+)
LP/J MGP_LPJ_G0015996
protein coding gene Chr1:61941743-61963131 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0015946
protein coding gene Chr1:68353643-68376837 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016519
protein coding gene Chr1:60498927-60519771 (+)
PWK/PhJ MGP_PWKPhJ_G0015220
protein coding gene Chr1:57679425-57701573 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015000
protein coding gene Chr1:59998585-60033212 (+)
WSB/EiJ MGP_WSBEiJ_G0015496
protein coding gene Chr1:60180985-60205703 (+)



Homology
more
  • Human Ortholog
    ICOS, inducible T cell costimulator
  • Vertebrate Orthologs
    7
  • Human Ortholog
    ICOS, inducible T cell costimulator
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AILIM, CD278, CVID1
  • Links
    NCBI Gene ID: 29851
    neXtProt AC: NX_Q9Y6W8
    UniProt: Q9Y6W8

  • Chr Location
    2q33.2; chr2:203936748-203961577 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Icos mouse models; 1 with human ICOS associations

Human Disease Mouse Models
      
IDs
View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    54 phenotypes from 6 alleles in 8 genetic backgrounds
    4 phenotypes from multigenic genotypes
    90 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene show reduced basal IgG1 levels and impaired interactions between T and B cells. T cell dependent B cell isotype switching was impaired as well.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000026009 Ensembl Gene Model | MGI Sequence Detail 22394 C57BL/6J ±  kb
transcript ENSMUST00000027162 Ensembl | MGI Sequence Detail 810 Not Applicable  
polypeptide ENSMUSP00000027162 Ensembl | MGI Sequence Detail 223 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    4 Sequences
  • InterPro Domains
    IPR013783 Immunoglobulin-like fold
    IPR013106 Immunoglobulin V-set domain
Molecular
Reagents
less
  • All nucleic 44
    cDNA 43
    Primer pair 1

    Microarray probesets 6
References
more
  • Summaries
    All 151
    Diseases 2
    Gene Ontology 8
    Phenotypes 90
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:261486 Panneton V, et al., ICOS Signaling Controls Induction and Maintenance of Collagen-Induced Arthritis. J Immunol. 2018 May 1;200(9):3067-3076

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory