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Icos
Gene Detail
Symbol

Name
ID
Icos
inducible T cell co-stimulator
MGI:1858745
Feature Type
protein coding gene
Genetic Map
Chromosome 1
30.60 cM
Detailed Genetic Map ± 1 cM


Mapping data(9)
Sequence Map
Chr1:60977927-61000320 bp, + strand
From VEGA annotation of GRCm38

  22394 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8097  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: ICOS
Protein SuperFamily: T-cell surface glycoprotein CD28
Gene Tree: Icos

Human
homologs
ICOS, inducible T-cell co-stimulator
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 29851
neXtProt AC: NX_Q9Y6W8

Human Synonyms: AILIM, CD278, CVID1

Human Chr (Location): 2q33; chr2:203936731-203961579 (+)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human ICOS

Mutations,
alleles, and
phenotypes
All mutations/alleles(14) : Targeted(14)
 
Mice homozygous for disruptions in this gene show reduced basal IgG1 levels and impaired interactions between T and B cells. T cell dependent B cell isotype switching was impaired as well.
 
Human Diseases Modeled in Mice Using Icos (1)    Mutations Annotated to Human Diseases (2)   
Interactions
Icos interacts with 361 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process single organismal cell-cell adhesion, T cell costimulation, ...
Component external side of plasma membrane, integral component of membrane, ...
Function protein binding
External Resources: FuncBase
Expression
cDNA source data(42)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(43) cDNA(42) Primer pair(1)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000002307 (Evidence)
Ensembl Gene Model ENSMUSG00000026009 (Evidence)
Entrez Gene 54167 (Evidence)
UniGene 42044
DFCI TC1583048, TC1641189, TC1634706
DoTS DT.528748, DT.487967
NIA Mouse Gene Index U042165
Consensus CDS Project CCDS14994.1
International Mouse Phenotyping Consortium Status Icos
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000002307 VEGA Gene Model | MGI Sequence Detail 22394 C57BL/6J ±  kb
transcript OTTMUST00000004596 VEGA | MGI Sequence Detail 810 Not Applicable 
polypeptide OTTMUSP00000002207 VEGA | MGI Sequence Detail 223 Not Applicable 

For the selected sequences
All sequences(56) RefSeq(22) UniProt(5)
Polymorphisms
PCR(1) : SNPs within 2kb(145 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
Protein Ontology PR:000001860 inducible T-cell costimulator
References
(Earliest) J:60318 Ling V, et al., Cutting edge: identification of GL50, a novel B7-like protein that functionally binds to ICOS receptor. J Immunol. 2000 Feb 15;164(4):1653-7
(Latest) J:209802 Gigoux M, et al., Inducible costimulator facilitates T-dependent B cell activation by augmenting IL-4 translation. Mol Immunol. 2014 May;59(1):46-54
All references(116)
Disease annotation references (2)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory