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Icos Gene Detail
Summary
  • Symbol
    Icos
  • Name
    inducible T cell co-stimulator
  • Feature Type
    protein coding gene
  • IDs
    MGI:1858745
    NCBI Gene: 54167
  • Gene Overview
    MyGene.info: ICOS
Location & Maps
more
  • Sequence Map
    Chr1:60977927-61000320 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      22394 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 30.60 cM
  • Mapping Data
    9 experiments
Homology
more
  • Human Ortholog
    ICOS, inducible T-cell costimulator
  • Vertebrate Orthologs
    7
  • Human Ortholog
    ICOS, inducible T-cell costimulator
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AILIM, CD278, CVID1
  • Links
    NCBI Gene ID: 29851
    neXtProt AC: NX_Q9Y6W8

  • Chr Location
    2q33.2; chr2:203936731-203961579 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Icos mouse models; 2 with human ICOS associations

Human Disease Mouse Models
       Immunodeficiency, Common Variable, 1; CVID1   OMIM: 607594 View 2 models
       Immunodeficiency, Common Variable, 2; CVID2   OMIM: 240500
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    54 phenotypes from 6 alleles in 8 genetic backgrounds
    4 phenotypes from multigenic genotypes
    83 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    17
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    15
  • Genomic Mutations
    2 involving Icos
Mice homozygous for disruptions in this gene show reduced basal IgG1 levels and impaired interactions between T and B cells. T cell dependent B cell isotype switching was impaired as well.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000002307 VEGA Gene Model | MGI Sequence Detail 22394 C57BL/6J ±  kb
transcript OTTMUST00000004596 VEGA | MGI Sequence Detail 810 Not Applicable  
polypeptide OTTMUSP00000002207 VEGA | MGI Sequence Detail 223 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    222 from dbSNP Build 142
  • PCR
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 43
    cDNA 42
    Primer pair 1

    Microarray probesets 6
References
more
  • Summaries
    All 123
    Diseases 2
    Gene Ontology 7
    Phenotypes 83
  • Earliest
    J:60318 Ling V, et al., Cutting edge: identification of GL50, a novel B7-like protein that functionally binds to ICOS receptor. J Immunol. 2000 Feb 15;164(4):1653-7
  • Latest
    J:233072 Masuda K, et al., Arid5a regulates naive CD4+ T cell fate through selective stabilization of Stat3 mRNA. J Exp Med. 2016 Apr 4;213(4):605-19

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory