Icos
Gene Detail

Symbol Name ID

Icos inducible T cell co-stimulator MGI:1858745

Feature Type

protein coding gene

Genetic Map

Chromosome 1

30.60 cM
Detailed Genetic Map ± 1 cM


Mapping data(9)

Sequence Map

Chr1:60977927-61000320 bp, + strand From VEGA annotation of GRCm38   22394 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:8097  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: T-cell surface glycoprotein CD28
Gene Tree: Icos

Human homologs

Human Homolog		ICOS, inducible T-cell co-stimulator
NCBI Gene ID		29851
neXtProt AC		NX_Q9Y6W8
Human Synonyms		AILIM, CD278, CVID1
Human Chr (Location)		2q33; chr2:204801471-204826300 (+)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human ICOS

Alleles and phenotypes

All alleles(14) : Targeted(14)
 

Mice homozygous for disruptions in this gene show reduced basal IgG1 levels and impaired interactions between T and B cells. T cell dependent B cell isotype switching was impaired as well.

 
Human Diseases Modeled Using Mouse Icos (1)    Alleles Annotated to Human Diseases(2)   

Gene Ontology (GO) classifications

All GO classifications: (5 annotations)

Component	external side of plasma membrane, integral to membrane, ...
Function	protein binding

External Resources: FuncBase

Expression

cDNA source data(42)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(43) cDNA(42) Primer pair(1)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000002307 (Evidence)
Ensembl Gene Model	ENSMUSG00000026009 (Evidence)
Entrez Gene	54167 (Evidence)
UniGene	42044
DFCI	TC1583048, TC1634706, TC1641189
DoTS	DT.487967, DT.528748
NIA Mouse Gene Index	U042165
Consensus CDS Project	CCDS14994.1
International Mouse Knockout Project Status	Icos

Sequences

Length	Strain/Species
genomic	OTTMUSG00000002307	VEGA Gene Model | MGI Sequence Detail	22394	C57BL/6J
transcript	OTTMUST00000004596	VEGA | MGI Sequence Detail	810	Not Applicable
polypeptide	OTTMUSP00000002207	VEGA | MGI Sequence Detail	223	Not Applicable

All sequences(35) RefSeq(2) UniProt(4)

Polymorphisms

PCR(1) : SNPs(126 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
Protein Ontology	PR:000001860	inducible T-cell costimulator

References

(Earliest) J:60318 Ling V, et al., Cutting edge: identification of GL50, a novel B7-like protein that functionally binds to ICOS receptor. J Immunol. 2000 Feb 15;164(4):1653-7
(Latest) J:193831 Redpath SA, et al., ICOS controls Foxp3(+) regulatory T-cell expansion, maintenance and IL-10 production during helminth infection. Eur J Immunol. 2013 Mar;43(3):705-15
All references(111)