Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes HSPB6
  • Mouse genes Hspb6
  • Rat genes Hspb6
  • Zfish genes hspb6
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Hspb6

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0044183	protein folding chaperone	HSPB6	IDA		Human	PMID:24382496
Molecular Function	GO:0042803	protein homodimerization activity	Hspb6	IPI	UniProtKB:P97541	Rat	PMID:19646995|RGD:8554166
Molecular Function	GO:0051087	protein-folding chaperone binding	HSPB6	IPI	UniProtKB:P04792	Human	PMID:23948568
Molecular Function	GO:0051082	unfolded protein binding	HSPB6	IDA		Human	PMID:19845507
Cellular Component	GO:0005737	cytoplasm	HSPB6	IDA		Human	PMID:19464326
Cellular Component	GO:0005829	cytosol	HSPB6	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005576	extracellular region	HSPB6	IDA		Human	PMID:22427880
Cellular Component	GO:0005739	mitochondrion	HSPB6	IDA		Human	GO_REF:0000052
Cellular Component	GO:0016607	nuclear speck	HSPB6	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	HSPB6	IDA		Human	PMID:19464326
Biological Process	GO:0061077	chaperone-mediated protein folding	HSPB6	IDA		Human	PMID:14717697
Biological Process	GO:0010667	negative regulation of cardiac muscle cell apoptotic process	Hspb6	IDA		Rat	PMID:15105294|RGD:12050134
Biological Process	GO:0045766	positive regulation of angiogenesis	HSPB6	IDA		Human	PMID:22427880
Biological Process	GO:0006937	regulation of muscle contraction	Hspb6	IEP		Rat	PMID:8921906|RGD:633218

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern