Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes HSD17B1
  • Mouse genes Hsd17b1
  • Rat genes Hsd17b1
  • Zfish genes hsd17b1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Hsd17b1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0072582	17-beta-hydroxysteroid dehydrogenase (NADP+) activity	Hsd17b1	IDA		Mouse	MGI:MGI:1267145|PMID:9658408
Molecular Function	GO:0004303	estradiol 17-beta-dehydrogenase [NAD(P)] activity	HSD17B1	IDA		Human	PMID:10625652
Molecular Function	GO:0004303	estradiol 17-beta-dehydrogenase [NAD(P)] activity	HSD17B1	IDA		Human	PMID:4396689
Molecular Function	GO:0004303	estradiol 17-beta-dehydrogenase [NAD(P)] activity	HSD17B1	IDA		Human	PMID:8994190
Molecular Function	GO:0004303	estradiol 17-beta-dehydrogenase [NAD(P)] activity	HSD17B1	IDA		Human	PMID:9525918
Molecular Function	GO:0004303	estradiol 17-beta-dehydrogenase [NAD(P)] activity	Hsd17b1	IDA		Mouse	MGI:MGI:1267145|PMID:9658408
Molecular Function	GO:0004303	estradiol 17-beta-dehydrogenase [NAD(P)] activity	Hsd17b1	IDA		Rat	PMID:8612487|RGD:728619
Molecular Function	GO:0004303	estradiol 17-beta-dehydrogenase [NAD(P)] activity	hsd17b1	IDA		Zfish	PMID:17467981
Molecular Function	GO:0004303	estradiol 17-beta-dehydrogenase [NAD(P)] activity	hsd17b1	IDA		Zfish	PMID:15026171
Molecular Function	GO:1903924	estradiol binding	HSD17B1	IDA		Human	PMID:10625652
Molecular Function	GO:0050661	NADP binding	HSD17B1	IDA		Human	PMID:8805577
Molecular Function	GO:0070401	NADP+ binding	HSD17B1	IMP		Human	PMID:9525918
Molecular Function	GO:0005515	protein binding	HSD17B1	IPI	UniProtKB:P09917	Human	PMID:32296183
Molecular Function	GO:0042803	protein homodimerization activity	HSD17B1	IDA		Human	PMID:8994190
Molecular Function	GO:0036094	small molecule binding	HSD17B1	EXP		Human	PMID:9525918
Molecular Function	GO:0005496	steroid binding	HSD17B1	IDA		Human	PMID:4396689
Molecular Function	GO:0016229	steroid dehydrogenase activity	hsd17b1	IDA		Zfish	PMID:17467981
Molecular Function	GO:0047035	testosterone dehydrogenase (NAD+) activity	Hsd17b1	IDA		Rat	PMID:8612487|RGD:728619
Molecular Function	GO:0030283	testosterone dehydrogenase [NAD(P)] activity	Hsd17b1	IDA		Mouse	MGI:MGI:1267145|PMID:9658408
Cellular Component	GO:0005737	cytoplasm	Hsd17b1	IDA		Rat	PMID:10682658|RGD:4890946
Cellular Component	GO:0005829	cytosol	HSD17B1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	Hsd17b1	IDA		Rat	PMID:16940216|RGD:4891018
Biological Process	GO:0060612	adipose tissue development	Hsd17b1	IMP	MGI:MGI:3799948	Mouse	PMID:29180785
Biological Process	GO:0008209	androgen metabolic process	hsd17b1	IDA		Zfish	PMID:17467981
Biological Process	GO:0060348	bone development	Hsd17b1	IEP		Rat	PMID:15012600|RGD:4891061
Biological Process	GO:0071248	cellular response to metal ion	Hsd17b1	IEP		Rat	PMID:18602937|RGD:4890967
Biological Process	GO:0006703	estrogen biosynthetic process	HSD17B1	IDA		Human	PMID:8994190
Biological Process	GO:0006703	estrogen biosynthetic process	Hsd17b1	IDA		Mouse	MGI:MGI:1267145|PMID:9658408
Biological Process	GO:0006703	estrogen biosynthetic process	Hsd17b1	IDA		Rat	PMID:8612487|RGD:728619
Biological Process	GO:0006703	estrogen biosynthetic process	hsd17b1	IDA		Zfish	PMID:15026171
Biological Process	GO:0006703	estrogen biosynthetic process	hsd17b1	IDA		Zfish	PMID:17467981
Biological Process	GO:0010467	gene expression	Hsd17b1	IMP	MGI:MGI:3799948	Mouse	PMID:29180785
Biological Process	GO:0006629	lipid metabolic process	Hsd17b1	IMP	MGI:MGI:3799948	Mouse	PMID:29180785
Biological Process	GO:0007040	lysosome organization	Hsd17b1	IMP	MGI:MGI:3799948	Mouse	PMID:29180785
Biological Process	GO:0007519	skeletal muscle tissue development	Hsd17b1	IMP	MGI:MGI:3799948	Mouse	PMID:29180785
Biological Process	GO:0061370	testosterone biosynthetic process	Hsd17b1	IDA		Mouse	MGI:MGI:1267145|PMID:9658408
Biological Process	GO:0061370	testosterone biosynthetic process	Hsd17b1	IDA		Rat	PMID:8612487|RGD:728619

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern