Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes HERC2
  • Mouse genes Herc2
  • Rat genes Herc2
  • Zfish genes herc2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Herc2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	HERC2	IPI	UniProtKB:O76064	Human	PMID:20023648
Molecular Function	GO:0005515	protein binding	HERC2	IPI	UniProtKB:P23025	Human	PMID:20304803
Molecular Function	GO:0005515	protein binding	HERC2	IPI	UniProtKB:Q9BXG8	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	HERC2	IPI	UniProtKB:Q05086-2	Human	PMID:29426014
Molecular Function	GO:0005515	protein binding	HERC2	IPI	UniProtKB:Q9BXG8	Human	PMID:35140242
Molecular Function	GO:0032183	SUMO binding	HERC2	IDA		Human	PMID:22508508
Molecular Function	GO:0061630	ubiquitin protein ligase activity	HERC2	IDA		Human	PMID:20304803
Molecular Function	GO:0031625	ubiquitin protein ligase binding	HERC2	IPI	UniProtKB:O76064	Human	PMID:22508508
Cellular Component	GO:0005737	cytoplasm	HERC2	IDA		Human	PMID:20304803
Cellular Component	GO:0005829	cytosol	HERC2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0016020	membrane	HERC2	HDA		Human	PMID:19946888
Cellular Component	GO:0005743	mitochondrial inner membrane	Herc2	HDA		Mouse	PMID:12865426
Cellular Component	GO:0005634	nucleus	HERC2	IDA		Human	PMID:20304803
Cellular Component	GO:0005886	plasma membrane	HERC2	IDA		Human	GO_REF:0000052
Biological Process	GO:0006974	DNA damage response	HERC2	IDA		Human	PMID:22508508
Biological Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Herc2	IMP		Mouse	MGI:MGI:5780912|PMID:26692333
Biological Process	GO:0016567	protein ubiquitination	HERC2	IDA		Human	PMID:20304803
Biological Process	GO:0007283	spermatogenesis	Herc2	IMP	MGI:MGI:1857705	Mouse	PMID:5565073
Biological Process	GO:0007283	spermatogenesis	Herc2	IMP	MGI:MGI:1857706	Mouse	MGI:MGI:60224
Biological Process	GO:0007283	spermatogenesis	Herc2	IMP	MGI:MGI:1857705	Mouse	MGI:MGI:60224
Biological Process	GO:0007283	spermatogenesis	Herc2	IMP	MGI:MGI:1857706	Mouse	PMID:5565073

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern