Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes HELB
  • Mouse genes Helb
  • Rat genes Helb
  • Zfish genes helb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Helb

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0043139	5'-3' DNA helicase activity	HELB	IDA		Human	PMID:12181327
Molecular Function	GO:0003678	DNA helicase activity	Helb	IDA		Mouse	PMID:11557815
Molecular Function	GO:0005515	protein binding	Helb	IPI	UniProtKB:Q5PPK9	Rat	PMID:27191843|RGD:11344934
Molecular Function	GO:0044877	protein-containing complex binding	HELB	IPI	ComplexPortal:CPX-2087	Human	PMID:12181327
Molecular Function	GO:0017116	single-stranded DNA helicase activity	HELB	IDA		Human	PMID:12181327
Cellular Component	GO:0005737	cytoplasm	HELB	IDA		Human	PMID:15146062
Cellular Component	GO:0005737	cytoplasm	Helb	IDA		Mouse	MGI:MGI:5766842|PMID:26774285
Cellular Component	GO:0005829	cytosol	HELB	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005739	mitochondrion	HELB	IDA		Human	GO_REF:0000052
Cellular Component	GO:0016604	nuclear body	HELB	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	HELB	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	HELB	IDA		Human	PMID:15146062
Cellular Component	GO:0005634	nucleus	Helb	IDA		Mouse	MGI:MGI:5766842|PMID:26774285
Cellular Component	GO:0035861	site of double-strand break	HELB	IMP		Human	PMID:26774285
Biological Process	GO:0006974	DNA damage response	HELB	IDA		Human	PMID:26774285
Biological Process	GO:0006974	DNA damage response	Helb	IMP		Mouse	MGI:MGI:5766842|PMID:26774285
Biological Process	GO:0006260	DNA replication	HELB	IMP		Human	PMID:12181327
Biological Process	GO:0006269	DNA replication, synthesis of RNA primer	HELB	IDA		Human	PMID:12181327
Biological Process	GO:0006261	DNA-templated DNA replication	Helb	IDA		Mouse	PMID:11557815
Biological Process	GO:2000042	negative regulation of double-strand break repair via homologous recombination	HELB	IMP		Human	PMID:26774285
Biological Process	GO:2000042	negative regulation of double-strand break repair via homologous recombination	Helb	IMP		Mouse	MGI:MGI:5766842|PMID:26774285
Biological Process	GO:1903775	regulation of DNA double-strand break processing	HELB	IMP		Human	PMID:26774285
Biological Process	GO:1903775	regulation of DNA double-strand break processing	Helb	IMP		Mouse	MGI:MGI:5766842|PMID:26774285

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern