Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes HEG1
  • Mouse genes Heg1
  • Rat genes Heg1
  • Zfish genes heg1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Heg1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	HEG1	IPI	UniProtKB:O00522	Human	PMID:23007647
Molecular Function	GO:0005515	protein binding	HEG1	IPI	UniProtKB:O00522	Human	PMID:26780829
Molecular Function	GO:0005515	protein binding	HEG1	IPI	UniProtKB:Q5U651	Human	PMID:26780829
Molecular Function	GO:0005515	protein binding	Heg1	IPI	UniProtKB:Q5U651	Mouse	MGI:MGI:5755186|PMID:26780829
Molecular Function	GO:0005515	protein binding	Heg1	IPI	PR:Q8K2Y9	Mouse	PMID:19151727
Cellular Component	GO:0009986	cell surface	Heg1	IDA		Mouse	PMID:19151727
Cellular Component	GO:0005911	cell-cell junction	HEG1	IDA		Human	PMID:26780829
Cellular Component	GO:0005911	cell-cell junction	Heg1	IDA		Mouse	PMID:19151727
Cellular Component	GO:0009897	external side of plasma membrane	Heg1	IDA		Mouse	PMID:19151727
Biological Process	GO:0003209	cardiac atrium morphogenesis	Heg1	IGI	MGI:MGI:2385159	Mouse	PMID:22898778
Biological Process	GO:0003209	cardiac atrium morphogenesis	Heg1	IMP	MGI:MGI:3838392	Mouse	PMID:19151727
Biological Process	GO:0055017	cardiac muscle tissue growth	Heg1	IGI	MGI:MGI:2385159	Mouse	PMID:22898778
Biological Process	GO:0007043	cell-cell junction assembly	heg1	IMP	ZFIN:ZDB-MRPHLNO-080714-5	Zfish	PMID:19151727
Biological Process	GO:0045216	cell-cell junction organization	Heg1	IMP	MGI:MGI:3838392	Mouse	PMID:19151727
Biological Process	GO:0001885	endothelial cell development	Heg1	IGI	MGI:MGI:2384924	Mouse	PMID:19151727
Biological Process	GO:0001886	endothelial cell morphogenesis	Heg1	IMP	MGI:MGI:3838392	Mouse	PMID:19151727
Biological Process	GO:0090269	fibroblast growth factor production	Heg1	IGI	MGI:MGI:2385159	Mouse	PMID:22898778
Biological Process	GO:0007507	heart development	Heg1	IGI	MGI:MGI:2384924	Mouse	PMID:19151727
Biological Process	GO:0007507	heart development	Heg1	IMP	MGI:MGI:3838392	Mouse	PMID:19151727
Biological Process	GO:0007507	heart development	heg1	IMP	ZFIN:ZDB-GENO-980202-467	Zfish	PMID:14680629
Biological Process	GO:0001701	in utero embryonic development	Heg1	IGI	MGI:MGI:2384924	Mouse	PMID:19151727
Biological Process	GO:0001701	in utero embryonic development	Heg1	IMP	MGI:MGI:3838392	Mouse	PMID:19151727
Biological Process	GO:0030324	lung development	Heg1	IMP	MGI:MGI:3838392	Mouse	PMID:19151727
Biological Process	GO:0003017	lymph circulation	Heg1	IMP	MGI:MGI:3838392	Mouse	PMID:19151727
Biological Process	GO:0001945	lymph vessel development	Heg1	IMP	MGI:MGI:3838392	Mouse	PMID:19151727
Biological Process	GO:0035264	multicellular organism growth	Heg1	IGI	MGI:MGI:2384924	Mouse	PMID:19151727
Biological Process	GO:1905709	negative regulation of membrane permeability	HEG1	IDA		Human	PMID:26780829
Biological Process	GO:0035024	negative regulation of Rho protein signal transduction	HEG1	IMP		Human	PMID:26780829
Biological Process	GO:2000299	negative regulation of Rho-dependent protein serine/threonine kinase activity	HEG1	IDA		Human	PMID:26780829
Biological Process	GO:0060039	pericardium development	Heg1	IMP	MGI:MGI:3838392	Mouse	PMID:19151727
Biological Process	GO:0060039	pericardium development	Heg1	IGI	MGI:MGI:2384924	Mouse	PMID:19151727
Biological Process	GO:0090271	positive regulation of fibroblast growth factor production	Heg1	IGI	MGI:MGI:2385159	Mouse	PMID:22898778
Biological Process	GO:0009791	post-embryonic development	Heg1	IMP	MGI:MGI:3838392	Mouse	PMID:19151727
Biological Process	GO:1902414	protein localization to cell junction	HEG1	IMP		Human	PMID:26780829
Biological Process	GO:0050878	regulation of body fluid levels	Heg1	IMP	MGI:MGI:3838392	Mouse	PMID:19151727
Biological Process	GO:0001944	vasculature development	Heg1	IGI	MGI:MGI:2384924	Mouse	PMID:19151727
Biological Process	GO:0001570	vasculogenesis	Heg1	IGI	MGI:MGI:2384924	Mouse	PMID:19151727
Biological Process	GO:0048845	venous blood vessel morphogenesis	Heg1	IGI	MGI:MGI:2384924	Mouse	PMID:19151727
Biological Process	GO:0003281	ventricular septum development	Heg1	IMP	MGI:MGI:3838392	Mouse	PMID:19151727
Biological Process	GO:0003222	ventricular trabecula myocardium morphogenesis	Heg1	IGI	MGI:MGI:2385159	Mouse	PMID:22898778

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern