Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes HCN3
  • Mouse genes Hcn3
  • Rat genes Hcn3
  • Zfish genes hcn3
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Hcn3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	HCN3	IPI	UniProtKB:Q4ACU6-1	Human	PMID:26966193
Molecular Function	GO:0005515	protein binding	Hcn3	IPI	UniProtKB:Q8BFX3|UniProtKB:Q8C437	Mouse	MGI:MGI:5527137|PMID:23382386
Molecular Function	GO:0005515	protein binding	Hcn3	IPI	PR:Q8C437	Mouse	PMID:15564593
Molecular Function	GO:0005249	voltage-gated potassium channel activity	HCN3	IMP		Human	PMID:22748890
Molecular Function	GO:0005249	voltage-gated potassium channel activity	Hcn3	IDA		Mouse	MGI:MGI:3589863|PMID:15923185
Molecular Function	GO:0005248	voltage-gated sodium channel activity	HCN3	IMP		Human	PMID:22748890
Cellular Component	GO:0030424	axon	Hcn3	IDA		Rat	PMID:14991560|RGD:9686394
Cellular Component	GO:0044316	cone cell pedicle	Hcn3	IDA		Rat	PMID:12786975|RGD:1299239
Cellular Component	GO:0030425	dendrite	Hcn3	IDA		Rat	PMID:14991560|RGD:9686394
Cellular Component	GO:0016020	membrane	Hcn3	IDA		Mouse	PMID:30886335
Cellular Component	GO:0043025	neuronal cell body	Hcn3	IDA		Rat	PMID:14991560|RGD:9686394
Cellular Component	GO:0005886	plasma membrane	HCN3	IDA		Human	PMID:22748890
Cellular Component	GO:0005886	plasma membrane	Hcn3	IDA		Mouse	MGI:MGI:5527137|PMID:23382386
Cellular Component	GO:0005886	plasma membrane	Hcn3	IDA		Mouse	MGI:MGI:3589863|PMID:15923185
Cellular Component	GO:0005886	plasma membrane	Hcn3	IDA		Rat	PMID:14991560|RGD:9686394
Cellular Component	GO:0045202	synapse	Hcn3	IDA		Rat	PMID:12786975|RGD:1299239
Biological Process	GO:0071320	cellular response to cAMP	HCN3	IDA		Human	PMID:16043489
Biological Process	GO:1903351	cellular response to dopamine	Hcn3	IEP		Rat	PMID:19320057|RGD:9693679
Biological Process	GO:0071805	potassium ion transmembrane transport	HCN3	IMP		Human	PMID:22748890
Biological Process	GO:0071805	potassium ion transmembrane transport	Hcn3	IDA		Mouse	MGI:MGI:3589863|PMID:15923185
Biological Process	GO:0003254	regulation of membrane depolarization	HCN3	IDA		Human	PMID:16043489
Biological Process	GO:0042391	regulation of membrane potential	HCN3	IMP		Human	PMID:22748890
Biological Process	GO:0072718	response to cisplatin	Hcn3	IEP		Rat	PMID:19584356|RGD:2316614
Biological Process	GO:0035725	sodium ion transmembrane transport	HCN3	IMP		Human	PMID:22748890

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern