Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes HCLS1
  • Mouse genes Hcls1
  • Rat genes Hcls1
  • Zfish genes hcls1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Hcls1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	HCLS1	IPI	UniProtKB:Q9H788	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	HCLS1	IPI	UniProtKB:P54274	Human	PMID:21044950
Molecular Function	GO:0005515	protein binding	HCLS1	IPI	UniProtKB:O43516	Human	PMID:21398607
Molecular Function	GO:0005515	protein binding	HCLS1	IPI	UniProtKB:Q9H788	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	HCLS1	IPI	UniProtKB:Q9H788	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	HCLS1	IPI	UniProtKB:P78314-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HCLS1	IPI	UniProtKB:Q9H788	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Hcls1	IPI	UniProtKB:P06240|UniProtKB:P25911|UniProtKB:P39688	Mouse	MGI:MGI:3694161|PMID:10713104
Molecular Function	GO:0005515	protein binding	Hcls1	IPI	UniProtKB:P25911	Mouse	MGI:MGI:3694161|PMID:10713104
Molecular Function	GO:0005515	protein binding	Hcls1	IPI	PR:P20489	Mouse	PMID:7506729
Molecular Function	GO:0005515	protein binding	Hcls1	IPI	PR:Q3TC93	Mouse	PMID:10590261
Molecular Function	GO:0005515	protein binding	Hcls1	IPI	PR:Q91WK7	Mouse	PMID:19064729
Molecular Function	GO:0019901	protein kinase binding	HCLS1	IPI	UniProtKB:P07948	Human	PMID:23001182
Molecular Function	GO:0019901	protein kinase binding	HCLS1	IPI	UniProtKB:P43405	Human	PMID:23001182
Molecular Function	GO:0044877	protein-containing complex binding	Hcls1	IPI	PR:Q91WK7	Mouse	PMID:19064729
Molecular Function	GO:0044877	protein-containing complex binding	Hcls1	IPI	PR:P25911	Mouse	PMID:19064729
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	HCLS1	IPI	UniProtKB:Q9UJU2	Human	PMID:23001182
Molecular Function	GO:0017124	SH3 domain binding	Hcls1	IDA		Mouse	PMID:9126384
Molecular Function	GO:0017124	SH3 domain binding	Hcls1	IPI	PR:Q91WK7	Mouse	PMID:19064729
Cellular Component	GO:0005737	cytoplasm	HCLS1	IDA		Human	PMID:23001182
Cellular Component	GO:0005737	cytoplasm	Hcls1	IDA		Mouse	MGI:MGI:3694161|PMID:10713104
Cellular Component	GO:0005829	cytosol	HCLS1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	HCLS1	IDA		Human	PMID:23001182
Cellular Component	GO:0005634	nucleus	Hcls1	IDA		Mouse	MGI:MGI:3694161|PMID:10713104
Cellular Component	GO:0005886	plasma membrane	HCLS1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005667	transcription regulator complex	HCLS1	IDA		Human	PMID:23001182
Biological Process	GO:0071345	cellular response to cytokine stimulus	HCLS1	IMP		Human	PMID:23001182
Biological Process	GO:0030218	erythrocyte differentiation	Hcls1	IMP		Mouse	MGI:MGI:3694161|PMID:10713104
Biological Process	GO:2000107	negative regulation of leukocyte apoptotic process	HCLS1	IMP		Human	PMID:23001182
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Hcls1	IMP		Mouse	MGI:MGI:5448611|PMID:23001182
Biological Process	GO:0008284	positive regulation of cell population proliferation	Hcls1	IMP		Mouse	MGI:MGI:3694161|PMID:10713104
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	HCLS1	IMP		Human	PMID:23001182
Biological Process	GO:0030854	positive regulation of granulocyte differentiation	HCLS1	IMP		Human	PMID:23001182
Biological Process	GO:0030854	positive regulation of granulocyte differentiation	Hcls1	IMP		Mouse	MGI:MGI:5448611|PMID:23001182
Biological Process	GO:0045651	positive regulation of macrophage differentiation	Hcls1	IMP		Mouse	MGI:MGI:5448611|PMID:23001182
Biological Process	GO:0033138	positive regulation of peptidyl-serine phosphorylation	HCLS1	IMP		Human	PMID:23001182
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	HCLS1	IMP		Human	PMID:23001182
Biological Process	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	HCLS1	IMP		Human	PMID:23001182
Biological Process	GO:0042307	positive regulation of protein import into nucleus	HCLS1	IMP		Human	PMID:23001182
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	HCLS1	IMP		Human	PMID:23001182
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	HCLS1	IMP		Human	PMID:23001182
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Hcls1	IMP		Mouse	MGI:MGI:5448611|PMID:23001182
Biological Process	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	Hcls1	IMP		Mouse	MGI:MGI:3694161|PMID:10713104
Biological Process	GO:0030833	regulation of actin filament polymerization	HCLS1	IMP		Human	PMID:23001182
Biological Process	GO:0009725	response to hormone	Hcls1	IDA		Mouse	MGI:MGI:3694161|PMID:10713104

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern