Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes HAX1
  • Mouse genes Hax1
  • Rat genes Hax1
  • Zfish genes hax1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Hax1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0019966	interleukin-1 binding	HAX1	IDA		Human	PMID:11554782
Molecular Function	GO:0005515	protein binding	HAX1	IPI	UniProtKB:P01583	Human	PMID:16971486
Molecular Function	GO:0005515	protein binding	HAX1	IPI	UniProtKB:Q99623	Human	PMID:17008324
Molecular Function	GO:0005515	protein binding	HAX1	IPI	UniProtKB:P42858	Human	PMID:17500595
Molecular Function	GO:0005515	protein binding	HAX1	IPI	UniProtKB:P98170	Human	PMID:20171186
Molecular Function	GO:0005515	protein binding	HAX1	IPI	UniProtKB:Q9BRX2	Human	PMID:20406461
Molecular Function	GO:0005515	protein binding	HAX1	IPI	UniProtKB:Q68871	Human	PMID:20631090
Molecular Function	GO:0005515	protein binding	HAX1	IPI	UniProtKB:Q14451	Human	PMID:20665473
Molecular Function	GO:0005515	protein binding	HAX1	IPI	UniProtKB:P03372	Human	PMID:21217774
Molecular Function	GO:0005515	protein binding	HAX1	IPI	UniProtKB:Q9H4B6	Human	PMID:21567072
Molecular Function	GO:0005515	protein binding	HAX1	IPI	UniProtKB:Q9H4B6	Human	PMID:22570112
Molecular Function	GO:0005515	protein binding	HAX1	IPI	UniProtKB:Q8NHX9	Human	PMID:24188827
Molecular Function	GO:0005515	protein binding	HAX1	IPI	UniProtKB:Q9ULQ1	Human	PMID:24188827
Molecular Function	GO:0005515	protein binding	HAX1	IPI	UniProtKB:P01583	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	HAX1	IPI	UniProtKB:P56501	Human	PMID:26915802
Molecular Function	GO:0005515	protein binding	HAX1	IPI	UniProtKB:P42858	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HAX1	IPI	UniProtKB:P61981	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HAX1	IPI	UniProtKB:Q15047-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HAX1	IPI	UniProtKB:Q8TAP4-4	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HAX1	IPI	UniProtKB:Q92993	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Hax1	IPI	UniProtKB:P56501	Mouse	MGI:MGI:6880400|PMID:26915802
Molecular Function	GO:0005515	protein binding	Hax1	IPI	UniProtKB:P42227|UniProtKB:Q8BWG8	Mouse	MGI:MGI:3688344|PMID:15102471
Molecular Function	GO:0005515	protein binding	Hax1	IPI	UniProtKB:Q5XJY4|UniProtKB:Q9JIY5	Mouse	MGI:MGI:3776580|PMID:18288109
Molecular Function	GO:0005515	protein binding	Hax1	IPI	UniProtKB:Q13563	Mouse	MGI:MGI:5142388|PMID:10760273
Molecular Function	GO:0005515	protein binding	Hax1	IPI	RGD:619839	Rat	PMID:15159385|RGD:1302732
Molecular Function	GO:0005515	protein binding	Hax1	IPI	UniProtKB:O70127	Rat	PMID:15159385|RGD:1302732
Molecular Function	GO:0005515	protein binding	Hax1	IPI	UniProtKB:Q08201	Rat	PMID:15159385|RGD:1302732
Molecular Function	GO:0005515	protein binding	Hax1	IPI	UniProtKB:Q6PSM0	Rat	PMID:15159385|RGD:1302732
Molecular Function	GO:0019904	protein domain specific binding	Hax1	IPI	RGD:620248|RGD:619951|RGD:619930	Rat	PMID:15159385|RGD:1302732
Cellular Component	GO:0015629	actin cytoskeleton	Hax1	IDA		Mouse	MGI:MGI:5142388|PMID:10760273
Cellular Component	GO:0016324	apical plasma membrane	Hax1	IDA		Rat	PMID:15159385|RGD:1302732
Cellular Component	GO:0030136	clathrin-coated vesicle	Hax1	IDA		Rat	PMID:15159385|RGD:1302732
Cellular Component	GO:0005737	cytoplasm	Hax1	IDA		Mouse	MGI:MGI:5142388|PMID:10760273
Cellular Component	GO:0005783	endoplasmic reticulum	Hax1	IDA		Mouse	MGI:MGI:5142388|PMID:10760273
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	Hax1	IDA		Rat	PMID:15159385|RGD:1302732
Cellular Component	GO:0030027	lamellipodium	Hax1	IDA		Mouse	MGI:MGI:5142388|PMID:10760273
Cellular Component	GO:0005758	mitochondrial intermembrane space	HAX1	IDA		Human	PMID:17008324
Cellular Component	GO:0005759	mitochondrial matrix	Hax1	IDA		Mouse	MGI:MGI:6880400|PMID:26915802
Cellular Component	GO:0005741	mitochondrial outer membrane	HAX1	IDA		Human	PMID:17008324
Cellular Component	GO:0005739	mitochondrion	HAX1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005739	mitochondrion	HAX1	IDA		Human	PMID:9058808
Cellular Component	GO:0005739	mitochondrion	Hax1	HDA		Mouse	PMID:14651853
Cellular Component	GO:0005739	mitochondrion	Hax1	IDA		Mouse	PMID:9058808
Cellular Component	GO:0016529	sarcoplasmic reticulum	Hax1	IDA		Mouse	MGI:MGI:4414726|PMID:19920172
Cellular Component	GO:0016529	sarcoplasmic reticulum	Hax1	IDA		Rat	PMID:19920172|RGD:10047287
Cellular Component	GO:0005667	transcription regulator complex	HAX1	IDA		Human	PMID:23001182
Biological Process	GO:0071345	cellular response to cytokine stimulus	HAX1	IMP		Human	PMID:23001182
Biological Process	GO:0043066	negative regulation of apoptotic process	HAX1	IMP		Human	PMID:17008324
Biological Process	GO:0030223	neutrophil differentiation	hax1	IMP	ZFIN:ZDB-MRPHLNO-211229-1	Zfish	PMID:32327498
Biological Process	GO:0030223	neutrophil differentiation	hax1	IMP	ZFIN:ZDB-MRPHLNO-211229-3	Zfish	PMID:32327498
Biological Process	GO:0030223	neutrophil differentiation	hax1	IMP	ZFIN:ZDB-MRPHLNO-211229-2	Zfish	PMID:32327498
Biological Process	GO:0030223	neutrophil differentiation	hax1	IMP	ZFIN:ZDB-CRISPR-211229-1	Zfish	PMID:32327498
Biological Process	GO:2000251	positive regulation of actin cytoskeleton reorganization	HAX1	IMP		Human	PMID:23001182
Biological Process	GO:0030854	positive regulation of granulocyte differentiation	HAX1	IMP		Human	PMID:23001182
Biological Process	GO:0033138	positive regulation of peptidyl-serine phosphorylation	HAX1	IMP		Human	PMID:23001182
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	HAX1	IMP		Human	PMID:23001182
Biological Process	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	HAX1	IMP		Human	PMID:23001182
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	HAX1	IMP		Human	PMID:23001182
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	HAX1	IMP		Human	PMID:23001182
Biological Process	GO:0030833	regulation of actin filament polymerization	HAX1	IMP		Human	PMID:23001182

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern