Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes HACE1
  • Mouse genes Hace1
  • Rat genes Hace1
  • Zfish genes hace1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Hace1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	HACE1	IPI	UniProtKB:P63000	Human	PMID:22614015
Molecular Function	GO:0005515	protein binding	HACE1	IPI	UniProtKB:Q96CV9	Human	PMID:25026213
Molecular Function	GO:0005515	protein binding	HACE1	IPI	UniProtKB:P20338	Human	PMID:32296183
Molecular Function	GO:0031267	small GTPase binding	HACE1	IDA		Human	PMID:21988917
Molecular Function	GO:0031267	small GTPase binding	HACE1	IPI	UniProtKB:P63000	Human	PMID:22036506
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	HACE1	IDA		Human	PMID:21988917
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	HACE1	IDA		Human	PMID:22036506
Cellular Component	GO:0005783	endoplasmic reticulum	HACE1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0000139	Golgi membrane	HACE1	IDA		Human	PMID:21988917
Cellular Component	GO:0016604	nuclear body	HACE1	IDA		Human	GO_REF:0000052
Biological Process	GO:0003190	atrioventricular valve formation	hace1	IMP	ZFIN:ZDB-MRPHLNO-130913-1	Zfish	PMID:29024245
Biological Process	GO:0003208	cardiac ventricle morphogenesis	hace1	IMP	ZFIN:ZDB-MRPHLNO-130913-1	Zfish	PMID:29024245
Biological Process	GO:0007030	Golgi organization	HACE1	IDA		Human	PMID:21988917
Biological Process	GO:0001947	heart looping	hace1	IMP	ZFIN:ZDB-MRPHLNO-130913-1	Zfish	PMID:29024245
Biological Process	GO:0061025	membrane fusion	HACE1	IMP		Human	PMID:21988917
Biological Process	GO:1903427	negative regulation of reactive oxygen species biosynthetic process	hace1	IGI	ZFIN:ZDB-MRPHLNO-121211-3,ZFIN:ZDB-MRPHLNO-130913-1,ZFIN:ZDB-MRPHLNO-180424-1	Zfish	PMID:29024245
Biological Process	GO:1903427	negative regulation of reactive oxygen species biosynthetic process	hace1	IMP	ZFIN:ZDB-MRPHLNO-130913-1	Zfish	PMID:29024245
Biological Process	GO:0070936	protein K48-linked ubiquitination	HACE1	IDA		Human	PMID:22036506
Biological Process	GO:0016567	protein ubiquitination	HACE1	IDA		Human	PMID:21988917
Biological Process	GO:0030334	regulation of cell migration	HACE1	IMP		Human	PMID:22036506
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	HACE1	IDA		Human	PMID:22036506

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern