Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes GUCY2C
  • Mouse genes Gucy2c
  • Rat genes Gucy2c
  • Zfish genes gucy2ca,gucy2cb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Gucy2c

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004383	guanylate cyclase activity	GUCY2C	IDA		Human	PMID:11950846
Molecular Function	GO:0004383	guanylate cyclase activity	Gucy2c	IMP	MGI:MGI:2665316	Mouse	PMID:9294128
Molecular Function	GO:0004383	guanylate cyclase activity	Gucy2c	IDA		Rat	PMID:1701694|RGD:728418
Molecular Function	GO:0005515	protein binding	GUCY2C	IPI	UniProtKB:Q86UT5	Human	PMID:11950846
Molecular Function	GO:0005515	protein binding	GUCY2C	IPI	UniProtKB:Q86UT5-2	Human	PMID:11950846
Molecular Function	GO:0015643	toxic substance binding	Gucy2c	IDA		Rat	PMID:1701694|RGD:728418
Biological Process	GO:0006182	cGMP biosynthetic process	Gucy2c	IMP	MGI:MGI:2665316	Mouse	MGI:MGI:1097012|PMID:9294128
Biological Process	GO:0042127	regulation of cell population proliferation	Gucy2c	IGI	MGI:MGI:88039	Mouse	PMID:17681179
Biological Process	GO:0009636	response to toxic substance	Gucy2c	IMP	MGI:MGI:2665316	Mouse	PMID:9294128

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern