Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes GRM2
  • Mouse genes Grm2
  • Rat genes Grm2
  • Zfish genes grm2a,grm2b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Grm2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005246	calcium channel regulator activity	Grm2	IDA		Mouse	PMID:11584003
Molecular Function	GO:0005246	calcium channel regulator activity	Grm2	IDA		Mouse	PMID:7965099
Molecular Function	GO:0001641	group II metabotropic glutamate receptor activity	Grm2	IDA		Mouse	PMID:7965099
Molecular Function	GO:0001641	group II metabotropic glutamate receptor activity	Grm2	IMP		Rat	PMID:12837619|RGD:1298933
Molecular Function	GO:0005515	protein binding	GRM2	IPI	UniProtKB:P28223-1	Human	PMID:18297054
Molecular Function	GO:0005515	protein binding	GRM2	IPI	UniProtKB:Q58DX5	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	GRM2	IPI	UniProtKB:Q9UMX0-2	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	GRM2	IPI	UniProtKB:O14880	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GRM2	IPI	UniProtKB:O95484	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GRM2	IPI	UniProtKB:P00387	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GRM2	IPI	UniProtKB:P27105	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GRM2	IPI	UniProtKB:P57739	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GRM2	IPI	UniProtKB:Q13113	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GRM2	IPI	UniProtKB:Q13323	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GRM2	IPI	UniProtKB:Q13520	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GRM2	IPI	UniProtKB:Q5SR56	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GRM2	IPI	UniProtKB:Q5T8D3-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GRM2	IPI	UniProtKB:Q7Z7G2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GRM2	IPI	UniProtKB:Q8IWU4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GRM2	IPI	UniProtKB:Q8N3G9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GRM2	IPI	UniProtKB:Q8N4V1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GRM2	IPI	UniProtKB:Q8WUV1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GRM2	IPI	UniProtKB:Q8WV48	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GRM2	IPI	UniProtKB:Q96Q45-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GRM2	IPI	UniProtKB:Q9H2H9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GRM2	IPI	UniProtKB:Q9NR31	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GRM2	IPI	UniProtKB:Q9NWD8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GRM2	IPI	UniProtKB:P0DTC2	Human	PMID:34903715
Molecular Function	GO:0005515	protein binding	GRM2	IPI	UniProtKB:P27487	Human	PMID:34903715
Molecular Function	GO:0005515	protein binding	GRM2	IPI	UniProtKB:Q9BYF1	Human	PMID:34903715
Molecular Function	GO:0005515	protein binding	Grm2	IPI	UniProtKB:Q96S59	Rat	PMID:18555800|RGD:8554412
Molecular Function	GO:0005515	protein binding	Grm2	IPI	UniProtKB:P14842	Rat	PMID:19590495|RGD:8553550
Molecular Function	GO:0097110	scaffold protein binding	Grm2	IPI	UniProtKB:O14745	Rat	PMID:28392297|RGD:21201273
Molecular Function	GO:0097110	scaffold protein binding	Grm2	IPI	UniProtKB:Q8SQG9	Rat	PMID:28392297|RGD:21201273
Cellular Component	GO:0097449	astrocyte projection	Grm2	IDA		Rat	PMID:28392297|RGD:21201273
Cellular Component	GO:0030424	axon	Grm2	IDA		Rat	PMID:15993439|RGD:8553886
Cellular Component	GO:0030424	axon	Grm2	IDA		Rat	PMID:28392297|RGD:21201273
Cellular Component	GO:0098978	glutamatergic synapse	Grm2	IDA		Mouse	PMID:31735403
Cellular Component	GO:0098978	glutamatergic synapse	Grm2	EXP		Mouse	PMID:31735403
Cellular Component	GO:0043005	neuron projection	Grm2	IDA		Mouse	PMID:12074840
Cellular Component	GO:0042734	presynaptic membrane	Grm2	IDA		Rat	PMID:15993439|RGD:8553886
Biological Process	GO:0035095	behavioral response to nicotine	Grm2	IMP		Rat	PMID:28700935|RGD:38501064
Biological Process	GO:0033554	cellular response to stress	Grm2	IDA		Mouse	PMID:29024663
Biological Process	GO:0010467	gene expression	Grm2	IMP	MGI:MGI:1857988	Mouse	PMID:18720515
Biological Process	GO:0014047	glutamate secretion	Grm2	IDA		Rat	PMID:15993439|RGD:8553886
Biological Process	GO:0090461	intracellular glutamate homeostasis	Grm2	IGI	MGI:MGI:1347355	Mouse	PMID:29024663
Biological Process	GO:0060292	long-term synaptic depression	Grm2	IMP	MGI:MGI:1857988	Mouse	PMID:8662555
Biological Process	GO:0099171	presynaptic modulation of chemical synaptic transmission	Grm2	IDA		Mouse	PMID:31735403
Biological Process	GO:0099171	presynaptic modulation of chemical synaptic transmission	Grm2	EXP		Mouse	PMID:31735403
Biological Process	GO:0014059	regulation of dopamine secretion	Grm2	IMP		Rat	PMID:30283001|RGD:38501063
Biological Process	GO:0014048	regulation of glutamate secretion	Grm2	IMP		Rat	PMID:28700935|RGD:38501064
Biological Process	GO:0014048	regulation of glutamate secretion	Grm2	IMP		Rat	PMID:30283001|RGD:38501063
Biological Process	GO:0051896	regulation of protein kinase B signaling	Grm2	IMP	UniProtKB:Q8SQG9	Rat	PMID:28392297|RGD:21201273
Biological Process	GO:2001023	regulation of response to drug	Grm2	IMP		Rat	PMID:28700935|RGD:38501064
Biological Process	GO:2001023	regulation of response to drug	Grm2	IMP		Rat	PMID:30283001|RGD:38501063
Biological Process	GO:0042220	response to cocaine	Grm2	IMP		Rat	PMID:28700935|RGD:38501064

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern