Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes GRK6
  • Mouse genes Grk6
  • Rat genes Grk6
  • Zfish genes grk6
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Grk6

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0047696	beta-adrenergic receptor kinase activity	GRK6	IDA		Human	PMID:20038610
Molecular Function	GO:0047696	beta-adrenergic receptor kinase activity	GRK6	IMP		Human	PMID:20038610
Molecular Function	GO:0004703	G protein-coupled receptor kinase activity	Grk6	IDA		Rat	PMID:12810562|RGD:1299124
Molecular Function	GO:0005515	protein binding	GRK6	IPI	UniProtKB:P52205	Human	PMID:20729810
Molecular Function	GO:0005515	protein binding	GRK6	IPI	UniProtKB:P08238	Human	PMID:22939624
Molecular Function	GO:0005515	protein binding	GRK6	IPI	UniProtKB:P08238	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	GRK6	IPI	UniProtKB:P05067	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Grk6	IPI	UniProtKB:Q28619	Mouse	MGI:MGI:5508297|PMID:10446210
Cellular Component	GO:0005829	cytosol	Grk6	IDA		Rat	PMID:12810562|RGD:1299124
Cellular Component	GO:0016020	membrane	GRK6	HDA		Human	PMID:19946888
Cellular Component	GO:0005886	plasma membrane	Grk6	IDA		Rat	PMID:12810562|RGD:1299124
Biological Process	GO:0071222	cellular response to lipopolysaccharide	Grk6	IEP		Rat	PMID:23359120|RGD:13792782
Biological Process	GO:0002029	desensitization of G protein-coupled receptor signaling pathway	Grk6	IDA		Rat	PMID:12810562|RGD:1299124
Biological Process	GO:0002029	desensitization of G protein-coupled receptor signaling pathway	Grk6	IMP		Rat	PMID:17908240|RGD:7242040
Biological Process	GO:0010360	negative regulation of anion channel activity	Grk6	IMP		Rat	PMID:17170521|RGD:5684927
Biological Process	GO:0006468	protein phosphorylation	Grk6	IDA		Rat	PMID:12810562|RGD:1299124

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern