Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes GRK5
  • Mouse genes Grk5
  • Rat genes Grk5
  • Zfish genes grk5l
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Grk5

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0047696	beta-adrenergic receptor kinase activity	GRK5	IMP		Human	PMID:20038610
Molecular Function	GO:0005515	protein binding	GRK5	IPI	UniProtKB:P25103	Human	PMID:17986524
Molecular Function	GO:0005515	protein binding	GRK5	IPI	UniProtKB:P25963	Human	PMID:19008357
Molecular Function	GO:0005515	protein binding	GRK5	IPI	UniProtKB:P97288	Human	PMID:19661922
Molecular Function	GO:0005515	protein binding	GRK5	IPI	UniProtKB:P04637	Human	PMID:20124405
Molecular Function	GO:0005515	protein binding	Grk5	IPI	UniProtKB:Q9UQL6	Mouse	MGI:MGI:3806920|PMID:18711143
Molecular Function	GO:0004674	protein serine/threonine kinase activity	GRK5	IDA		Human	PMID:20124405
Cellular Component	GO:0005829	cytosol	GRK5	IDA		Human	GO_REF:0000052
Cellular Component	GO:0031965	nuclear membrane	GRK5	IDA		Human	GO_REF:0000052
Cellular Component	GO:0016607	nuclear speck	GRK5	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	GRK5	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	GRK5	IDA		Human	PMID:14976207
Cellular Component	GO:0005886	plasma membrane	GRK5	IDA		Human	PMID:17986524
Cellular Component	GO:0005886	plasma membrane	grk5l	IDA		Zfish	PMID:27618959
Biological Process	GO:0002029	desensitization of G protein-coupled receptor signaling pathway	Grk5	IMP		Rat	PMID:30075183|RGD:13792694
Biological Process	GO:0002029	desensitization of G protein-coupled receptor signaling pathway	Grk5	IMP		Rat	PMID:8626574|RGD:61618
Biological Process	GO:0007368	determination of left/right symmetry	grk5l	IMP	ZFIN:ZDB-MRPHLNO-110706-1	Zfish	PMID:23972986
Biological Process	GO:0035469	determination of pancreatic left/right asymmetry	grk5l	IMP	ZFIN:ZDB-MRPHLNO-110706-1	Zfish	PMID:27618959
Biological Process	GO:0045444	fat cell differentiation	Grk5	IMP		Mouse	MGI:MGI:5319565|PMID:22507984
Biological Process	GO:0001947	heart looping	grk5l	IMP	ZFIN:ZDB-MRPHLNO-110706-1	Zfish	PMID:27618959
Biological Process	GO:0106072	negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	Grk5	IMP		Rat	PMID:30075183|RGD:13792694
Biological Process	GO:0043066	negative regulation of apoptotic process	GRK5	IDA		Human	PMID:20124405
Biological Process	GO:0032007	negative regulation of TOR signaling	grk5l	IMP	ZFIN:ZDB-MRPHLNO-110706-1	Zfish	PMID:23972986
Biological Process	GO:0048709	oligodendrocyte differentiation	Grk5	IEP		Rat	PMID:24613411|RGD:13792699
Biological Process	GO:0008284	positive regulation of cell population proliferation	GRK5	IMP		Human	PMID:22099983
Biological Process	GO:0046777	protein autophosphorylation	GRK5	IDA		Human	PMID:14976207
Biological Process	GO:0051726	regulation of cell cycle	GRK5	IMP		Human	PMID:22099983
Biological Process	GO:1902017	regulation of cilium assembly	grk5l	IMP	ZFIN:ZDB-MRPHLNO-110706-1	Zfish	PMID:23972986
Biological Process	GO:0008277	regulation of G protein-coupled receptor signaling pathway	Grk5	IMP		Rat	PMID:8626574|RGD:61618
Biological Process	GO:0042220	response to cocaine	Grk5	IEP		Rat	PMID:25213649|RGD:13514050
Biological Process	GO:0043278	response to morphine	Grk5	IEP		Rat	PMID:12384166|RGD:727454
Biological Process	GO:0007217	tachykinin receptor signaling pathway	GRK5	IDA		Human	PMID:17986524

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern