Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes GLP1R
  • Mouse genes Glp1r
  • Rat genes Glp1r
  • Zfish genes gcgra,gcgrb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Glp1r

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008528	G protein-coupled peptide receptor activity	Glp1r	IPI	UniProtKB:P01275	Rat	PMID:8612565|RGD:1598447
Molecular Function	GO:0004967	glucagon receptor activity	gcgra	IDA		Zfish	PMID:19793957
Molecular Function	GO:0044508	glucagon-like peptide 1 receptor activity	GLP1R	IDA		Human	PMID:28514449
Molecular Function	GO:0017046	peptide hormone binding	Glp1r	IDA		Rat	PMID:1326760|RGD:727535
Molecular Function	GO:0017046	peptide hormone binding	gcgra	IPI	ZFIN:ZDB-GENE-040712-2	Zfish	PMID:26446275
Molecular Function	GO:0017046	peptide hormone binding	gcgra	IPI	ZFIN:ZDB-GENE-010219-1	Zfish	PMID:26446275
Molecular Function	GO:0017046	peptide hormone binding	gcgrb	IPI	ZFIN:ZDB-GENE-040712-2	Zfish	PMID:26446275
Molecular Function	GO:0017046	peptide hormone binding	gcgrb	IPI	ZFIN:ZDB-GENE-010219-1	Zfish	PMID:26446275
Molecular Function	GO:0017046	peptide hormone binding	gcgrb	IDA		Zfish	PMID:27930690
Molecular Function	GO:0017046	peptide hormone binding	gcgrb	IPI	ZFIN:ZDB-GENE-010219-1	Zfish	PMID:27930690
Molecular Function	GO:0017046	peptide hormone binding	gcgrb	IPI	ZFIN:ZDB-GENE-040712-2	Zfish	PMID:27930690
Molecular Function	GO:0001653	peptide receptor activity	Glp1r	IDA		Rat	PMID:15789279|RGD:1598438
Molecular Function	GO:0005515	protein binding	GLP1R	IPI	UniProtKB:P60409	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	GLP1R	IPI	UniProtKB:P60410	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	GLP1R	IPI	UniProtKB:P60411	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	GLP1R	IPI	UniProtKB:Q7Z3S9	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	GLP1R	IPI	UniProtKB:A8MQ03	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GLP1R	IPI	UniProtKB:P0DPK4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GLP1R	IPI	UniProtKB:P26371	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GLP1R	IPI	UniProtKB:Q07627	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GLP1R	IPI	UniProtKB:Q8IUG1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GLP1R	IPI	UniProtKB:Q9BYP8	Human	PMID:32296183
Cellular Component	GO:0005886	plasma membrane	GLP1R	IDA		Human	PMID:28514449
Cellular Component	GO:0005886	plasma membrane	Glp1r	IDA		Rat	PMID:16002551|RGD:1598459
Cellular Component	GO:0005886	plasma membrane	Glp1r	IDA		Rat	PMID:21046358|RGD:8553299
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	GLP1R	IDA		Human	PMID:28514449
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	Glp1r	IMP		Rat	PMID:8612565|RGD:1598447
Biological Process	GO:0008306	associative learning	Glp1r	IDA		Rat	PMID:12925848|RGD:1598440
Biological Process	GO:0019933	cAMP-mediated signaling	GLP1R	IDA		Human	PMID:7589461
Biological Process	GO:0019933	cAMP-mediated signaling	Glp1r	IMP		Rat	PMID:10446905|RGD:1598448
Biological Process	GO:0007631	feeding behavior	Glp1r	IMP		Rat	PMID:10933308|RGD:1624355
Biological Process	GO:0046879	hormone secretion	Glp1r	IMP	MGI:MGI:2150310	Mouse	PMID:23542788
Biological Process	GO:0046879	hormone secretion	Glp1r	IDA		Rat	PMID:8828468|RGD:8554483
Biological Process	GO:0030073	insulin secretion	Glp1r	IMP		Rat	PMID:10362617|RGD:8553736
Biological Process	GO:0007611	learning or memory	Glp1r	IMP		Mouse	MGI:MGI:2674184|PMID:12925848
Biological Process	GO:0007611	learning or memory	Glp1r	IMP		Rat	PMID:12925848|RGD:1598440
Biological Process	GO:0007613	memory	Glp1r	IDA		Rat	PMID:12925848|RGD:1598440
Biological Process	GO:0043066	negative regulation of apoptotic process	Glp1r	IDA		Rat	PMID:12409292|RGD:728487
Biological Process	GO:0045776	negative regulation of blood pressure	Glp1r	IMP	MGI:MGI:2150310	Mouse	PMID:23542788
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	Glp1r	IDA		Rat	PMID:12925848|RGD:1598440
Biological Process	GO:0045777	positive regulation of blood pressure	Glp1r	IDA		Mouse	MGI:MGI:5444823|PMID:21810595
Biological Process	GO:0045777	positive regulation of blood pressure	Glp1r	IDA		Rat	PMID:12093887|RGD:625448
Biological Process	GO:0045597	positive regulation of cell differentiation	Glp1r	IMP		Rat	PMID:10580413|RGD:1624356
Biological Process	GO:0008284	positive regulation of cell population proliferation	Glp1r	IMP		Rat	PMID:10580413|RGD:1624356
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	GLP1R	IDA		Human	PMID:7589461
Biological Process	GO:0045823	positive regulation of heart contraction	Glp1r	IDA		Rat	PMID:12093887|RGD:625448
Biological Process	GO:0032024	positive regulation of insulin secretion	Glp1r	IDA		Rat	PMID:12093887|RGD:625448
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Glp1r	IMP		Rat	PMID:11845326|RGD:728844
Biological Process	GO:0031204	post-translational protein targeting to membrane, translocation	Glp1r	IMP	MGI:MGI:2150310	Mouse	PMID:23542788
Biological Process	GO:0051924	regulation of calcium ion transport	Glp1r	IMP		Rat	PMID:10446905|RGD:1598448
Biological Process	GO:0010906	regulation of glucose metabolic process	gcgra	IMP	ZFIN:ZDB-GENO-160413-7	Zfish	PMID:26446275
Biological Process	GO:0010906	regulation of glucose metabolic process	gcgra	IGI	ZFIN:ZDB-GENO-160413-9	Zfish	PMID:26446275
Biological Process	GO:0010906	regulation of glucose metabolic process	gcgrb	IMP	ZFIN:ZDB-GENO-160413-8	Zfish	PMID:26446275
Biological Process	GO:0010906	regulation of glucose metabolic process	gcgrb	IGI	ZFIN:ZDB-GENO-160413-9	Zfish	PMID:26446275
Biological Process	GO:0008016	regulation of heart contraction	Glp1r	IMP		Mouse	MGI:MGI:2663341|PMID:12746281
Biological Process	GO:0051209	release of sequestered calcium ion into cytosol	Glp1r	IDA		Rat	PMID:15789279|RGD:1598438
Biological Process	GO:0009749	response to glucose	Glp1r	IMP		Rat	PMID:11845326|RGD:728844
Biological Process	GO:1990911	response to psychosocial stress	Glp1r	IMP		Mouse	MGI:MGI:1352946|PMID:10650957

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern