Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes GFRAL
  • Mouse genes Gfral
  • Rat genes Gfral
  • Zfish genes gfral
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Gfral

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0016167	glial cell-derived neurotrophic factor receptor activity	GFRAL	IDA		Human	PMID:28846097
Molecular Function	GO:0016167	glial cell-derived neurotrophic factor receptor activity	GFRAL	IDA		Human	PMID:28846098
Molecular Function	GO:0016167	glial cell-derived neurotrophic factor receptor activity	GFRAL	IDA		Human	PMID:28846099
Molecular Function	GO:0016167	glial cell-derived neurotrophic factor receptor activity	GFRAL	IDA		Human	PMID:28953886
Molecular Function	GO:0016167	glial cell-derived neurotrophic factor receptor activity	Gfral	IDA		Mouse	MGI:MGI:6103007|PMID:28846098
Molecular Function	GO:0016167	glial cell-derived neurotrophic factor receptor activity	Gfral	IDA		Mouse	MGI:MGI:6103585|PMID:28846099
Molecular Function	GO:0016167	glial cell-derived neurotrophic factor receptor activity	Gfral	IDA		Mouse	MGI:MGI:6103404|PMID:28846097
Molecular Function	GO:0005515	protein binding	GFRAL	IPI	UniProtKB:Q99988	Human	PMID:28846097
Molecular Function	GO:0005515	protein binding	GFRAL	IPI	UniProtKB:Q99988	Human	PMID:28846098
Molecular Function	GO:0005515	protein binding	GFRAL	IPI	UniProtKB:Q99988	Human	PMID:28846099
Molecular Function	GO:0005515	protein binding	GFRAL	IPI	UniProtKB:Q99988	Human	PMID:28953886
Molecular Function	GO:0005515	protein binding	Gfral	IPI	UniProtKB:Q99988	Mouse	MGI:MGI:6103585|PMID:28846099
Molecular Function	GO:0005515	protein binding	Gfral	IPI	UniProtKB:Q99988	Mouse	MGI:MGI:6103007|PMID:28846098
Molecular Function	GO:0030971	receptor tyrosine kinase binding	GFRAL	IPI	UniProtKB:P07949	Human	PMID:28846097
Molecular Function	GO:0030971	receptor tyrosine kinase binding	GFRAL	IPI	UniProtKB:P07949	Human	PMID:28846099
Molecular Function	GO:0030971	receptor tyrosine kinase binding	GFRAL	IPI	UniProtKB:P07949	Human	PMID:28953886
Molecular Function	GO:0030971	receptor tyrosine kinase binding	Gfral	IPI	UniProtKB:P35546	Mouse	MGI:MGI:6103585|PMID:28846099
Cellular Component	GO:0015629	actin cytoskeleton	GFRAL	IDA		Human	GO_REF:0000052
Cellular Component	GO:0009897	external side of plasma membrane	GFRAL	IDA		Human	PMID:28953886
Cellular Component	GO:0005925	focal adhesion	GFRAL	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	GFRAL	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	GFRAL	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	Gfral	IDA		Mouse	PMID:16086688
Biological Process	GO:0035860	glial cell-derived neurotrophic factor receptor signaling pathway	GFRAL	IDA		Human	PMID:28953886
Biological Process	GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	Gfral	IDA		Mouse	PMID:16086688
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	Gfral	IDA		Mouse	PMID:16086688
Biological Process	GO:0043410	positive regulation of MAPK cascade	GFRAL	IDA		Human	PMID:28846099
Biological Process	GO:0043410	positive regulation of MAPK cascade	GFRAL	IDA		Human	PMID:28953886
Biological Process	GO:0043410	positive regulation of MAPK cascade	Gfral	IMP		Mouse	MGI:MGI:6101250|PMID:28953886
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	GFRAL	IDA		Human	PMID:28846097
Biological Process	GO:0002023	reduction of food intake in response to dietary excess	Gfral	IMP		Mouse	MGI:MGI:6103007|PMID:28846098
Biological Process	GO:0002023	reduction of food intake in response to dietary excess	Gfral	IMP		Mouse	MGI:MGI:6101250|PMID:28953886
Biological Process	GO:0002023	reduction of food intake in response to dietary excess	Gfral	IDA		Mouse	MGI:MGI:6103404|PMID:28846097
Biological Process	GO:0002023	reduction of food intake in response to dietary excess	Gfral	IMP		Mouse	MGI:MGI:6103585|PMID:28846099
Biological Process	GO:0031098	stress-activated protein kinase signaling cascade	Gfral	IDA		Mouse	PMID:16086688

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern