Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes GDF2
  • Mouse genes Gdf2
  • Rat genes Gdf2
  • Zfish genes gdf2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Gdf2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0070700	BMP receptor binding	GDF2	IDA		Human	PMID:17311849
Molecular Function	GO:0005515	protein binding	GDF2	IPI	UniProtKB:P37023	Human	PMID:17068149
Molecular Function	GO:0005515	protein binding	Gdf2	IPI	UniProtKB:Q61288	Mouse	MGI:MGI:4830635|PMID:20406889
Molecular Function	GO:0043539	protein serine/threonine kinase activator activity	GDF2	IDA		Human	PMID:17311849
Molecular Function	GO:0030546	signaling receptor activator activity	GDF2	IDA		Human	PMID:17311849
Cellular Component	GO:0009986	cell surface	GDF2	IDA		Human	PMID:17311849
Cellular Component	GO:0070062	extracellular exosome	GDF2	HDA		Human	PMID:19056867
Biological Process	GO:0032924	activin receptor signaling pathway	GDF2	IDA		Human	PMID:17068149
Biological Process	GO:0001525	angiogenesis	GDF2	IMP		Human	PMID:23972370
Biological Process	GO:0001525	angiogenesis	gdf2	IMP		Zfish	PMID:23972370|ZFIN:ZDB-PUB-130904-34
Biological Process	GO:0001525	angiogenesis	gdf2	IMP	ZFIN:ZDB-MRPHLNO-131001-1	Zfish	PMID:23972370
Biological Process	GO:0048514	blood vessel morphogenesis	GDF2	IDA		Human	PMID:20406889
Biological Process	GO:0030509	BMP signaling pathway	GDF2	IDA		Human	PMID:17068149
Biological Process	GO:0030509	BMP signaling pathway	GDF2	IDA		Human	PMID:19366699
Biological Process	GO:0001569	branching involved in blood vessel morphogenesis	GDF2	IDA		Human	PMID:20406889
Biological Process	GO:0001569	branching involved in blood vessel morphogenesis	Gdf2	IDA		Mouse	MGI:MGI:4830635|PMID:20406889
Biological Process	GO:0071773	cellular response to BMP stimulus	GDF2	IDA		Human	PMID:19366699
Biological Process	GO:0030308	negative regulation of cell growth	GDF2	IDA		Human	PMID:17068149
Biological Process	GO:2000279	negative regulation of DNA biosynthetic process	GDF2	IDA		Human	PMID:19366699
Biological Process	GO:0010596	negative regulation of endothelial cell migration	GDF2	IDA		Human	PMID:17068149
Biological Process	GO:0001937	negative regulation of endothelial cell proliferation	GDF2	IDA		Human	PMID:20406889
Biological Process	GO:0001649	osteoblast differentiation	Gdf2	IGI	MGI:MGI:96396	Mouse	PMID:15161906
Biological Process	GO:0001649	osteoblast differentiation	Gdf2	IGI	MGI:MGI:96397	Mouse	PMID:15161906
Biological Process	GO:0001649	osteoblast differentiation	Gdf2	IGI	MGI:MGI:96398	Mouse	PMID:15161906
Biological Process	GO:0001649	osteoblast differentiation	Gdf2	IGI	MGI:MGI:1341800	Mouse	PMID:18986983
Biological Process	GO:0060389	pathway-restricted SMAD protein phosphorylation	GDF2	IDA		Human	PMID:17068149
Biological Process	GO:0045766	positive regulation of angiogenesis	GDF2	IDA		Human	PMID:20406889
Biological Process	GO:0045766	positive regulation of angiogenesis	Gdf2	IDA		Mouse	MGI:MGI:4830635|PMID:20406889
Biological Process	GO:0030513	positive regulation of BMP signaling pathway	Gdf2	IDA		Mouse	MGI:MGI:4830635|PMID:20406889
Biological Process	GO:0061036	positive regulation of cartilage development	Gdf2	IDA		Mouse	MGI:MGI:5621263|PMID:19956691
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	GDF2	IDA		Human	PMID:17068149
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Gdf2	IMP		Mouse	MGI:MGI:4830635|PMID:20406889
Biological Process	GO:0045603	positive regulation of endothelial cell differentiation	Gdf2	IDA		Mouse	MGI:MGI:4830635|PMID:20406889
Biological Process	GO:0001938	positive regulation of endothelial cell proliferation	GDF2	IDA		Human	PMID:20406889
Biological Process	GO:0001938	positive regulation of endothelial cell proliferation	Gdf2	IDA		Mouse	MGI:MGI:4830635|PMID:20406889
Biological Process	GO:0010628	positive regulation of gene expression	Gdf2	IDA		Mouse	PMID:22783020
Biological Process	GO:0032757	positive regulation of interleukin-8 production	GDF2	IDA		Human	PMID:19366699
Biological Process	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	GDF2	IDA		Human	PMID:17068149
Biological Process	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	GDF2	IDA		Human	PMID:19366699
Biological Process	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	GDF2	IDA		Human	PMID:19903896
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	GDF2	IDA		Human	PMID:19366699
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Gdf2	IGI	MGI:MGI:894293	Mouse	PMID:18986983
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Gdf2	IDA		Mouse	PMID:18997172
Biological Process	GO:0006366	transcription by RNA polymerase II	Gdf2	IDA		Mouse	PMID:18997172
Biological Process	GO:0001570	vasculogenesis	Gdf2	IDA		Mouse	MGI:MGI:4830635|PMID:20406889

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern