Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Gch1

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes GCH1
- Mouse genes Gch1
- Rat genes Gch1
- Zfish genes gch1,gch2
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Gch1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005509	calcium ion binding	Gch1	IDA		Rat	PMID:9636709\|RGD:2298655
Molecular Function	GO:0005525	GTP binding	GCH1	IDA		Human	PMID:14717702
Molecular Function	GO:0005525	GTP binding	GCH1	IDA		Human	PMID:3753653
Molecular Function	GO:0005525	GTP binding	Gch1	IDA		Rat	PMID:2557335\|RGD:2298653
Molecular Function	GO:0005525	GTP binding	Gch1	IDA		Rat	PMID:8486153\|RGD:2298654
Molecular Function	GO:0005525	GTP binding	Gch1	IDA		Rat	PMID:8702680\|RGD:728623
Molecular Function	GO:0003934	GTP cyclohydrolase I activity	GCH1	IDA		Human	PMID:16778797
Molecular Function	GO:0003934	GTP cyclohydrolase I activity	GCH1	IDA		Human	PMID:7730309
Molecular Function	GO:0003934	GTP cyclohydrolase I activity	Gch1	IDA		Mouse	PMID:7524491
Molecular Function	GO:0003934	GTP cyclohydrolase I activity	Gch1	IDA		Rat	PMID:12051753\|RGD:625450
Molecular Function	GO:0003934	GTP cyclohydrolase I activity	Gch1	IDA		Rat	PMID:15292175\|RGD:1601284
Molecular Function	GO:0003934	GTP cyclohydrolase I activity	Gch1	IDA		Rat	PMID:2557335\|RGD:2298653
Molecular Function	GO:0003934	GTP cyclohydrolase I activity	Gch1	IDA		Rat	PMID:8486153\|RGD:2298654
Molecular Function	GO:0003934	GTP cyclohydrolase I activity	Gch1	IDA		Rat	PMID:8702680\|RGD:728623
Molecular Function	GO:0003934	GTP cyclohydrolase I activity	Gch1	IDA		Rat	PMID:9636709\|RGD:2298655
Molecular Function	GO:0030742	GTP-dependent protein binding	Gch1	IPI	RGD:621746	Rat	PMID:9685352\|RGD:2298656
Molecular Function	GO:0003924	GTPase activity	GCH1	IDA		Human	PMID:2463916
Molecular Function	GO:0042802	identical protein binding	GCH1	IPI	UniProtKB:P30793	Human	PMID:11087827
Molecular Function	GO:0042802	identical protein binding	Gch1	IDA		Rat	PMID:2557335\|RGD:2298653
Molecular Function	GO:0042802	identical protein binding	Gch1	IDA		Rat	PMID:9636709\|RGD:2298655
Molecular Function	GO:0051019	mitogen-activated protein kinase binding	GCH1	IPI	UniProtKB:P53778	Human	PMID:19294699
Molecular Function	GO:0051019	mitogen-activated protein kinase binding	GCH1	IPI	UniProtKB:P53779	Human	PMID:19294699
Molecular Function	GO:0005515	protein binding	GCH1	IPI	UniProtKB:O95433	Human	PMID:16696853
Molecular Function	GO:0005515	protein binding	GCH1	IPI	UniProtKB:P30047	Human	PMID:16696853
Molecular Function	GO:0005515	protein binding	GCH1	IPI	UniProtKB:P68400	Human	PMID:19294699
Molecular Function	GO:0005515	protein binding	GCH1	IPI	UniProtKB:P63104	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	GCH1	IPI	UniProtKB:O14787-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GCH1	IPI	UniProtKB:Q9Y5L0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GCH1	IPI	UniProtKB:P30047	Human	PMID:9092499
Molecular Function	GO:0005515	protein binding	Gch1	IPI	UniProtKB:P70552	Rat	PMID:11818540\|RGD:2298660
Molecular Function	GO:0005515	protein binding	Gch1	IPI	UniProtKB:P70552	Rat	PMID:15448133\|RGD:1601286
Molecular Function	GO:0005515	protein binding	Gch1	IPI	RGD:620073	Rat	PMID:7802677\|RGD:2314916
Molecular Function	GO:0005515	protein binding	Gch1	IPI	RGD:621746	Rat	PMID:8702680\|RGD:728623
Molecular Function	GO:0042803	protein homodimerization activity	GCH1	IPI	UniProtKB:P30793	Human	PMID:16696853
Molecular Function	GO:0044877	protein-containing complex binding	Gch1	IDA		Rat	PMID:11818540\|RGD:2298660
Molecular Function	GO:0044877	protein-containing complex binding	Gch1	IPI	RGD:621746	Rat	PMID:15448133\|RGD:1601286
Molecular Function	GO:0044877	protein-containing complex binding	Gch1	IDA		Rat	PMID:9685352\|RGD:2298656
Molecular Function	GO:0031369	translation initiation factor binding	Gch1	IPI	RGD:1584560	Rat	PMID:22479495\|RGD:10755507
Molecular Function	GO:0008270	zinc ion binding	GCH1	IDA		Human	PMID:11087827
Molecular Function	GO:0008270	zinc ion binding	GCH1	IDA		Human	PMID:14717702
Molecular Function	GO:0008270	zinc ion binding	Gch1	IDA		Rat	PMID:11818540\|RGD:2298660
Molecular Function	GO:0008270	zinc ion binding	Gch1	IDA		Rat	PMID:15448133\|RGD:1601286
Cellular Component	GO:0005737	cytoplasm	GCH1	IDA		Human	PMID:10907721
Cellular Component	GO:0031410	cytoplasmic vesicle	GCH1	IDA		Human	PMID:3318829
Cellular Component	GO:0005829	cytosol	GCH1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	GCH1	IDA		Human	PMID:2463916
Cellular Component	GO:0005829	cytosol	GCH1	IDA		Human	PMID:3318829
Cellular Component	GO:0031965	nuclear membrane	GCH1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	GCH1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	GCH1	IDA		Human	PMID:16778797
Cellular Component	GO:0032991	protein-containing complex	GCH1	IDA		Human	PMID:11087823
Cellular Component	GO:0032991	protein-containing complex	Gch1	IDA		Rat	PMID:11818540\|RGD:2298660
Cellular Component	GO:0032991	protein-containing complex	Gch1	IDA		Rat	PMID:15448133\|RGD:1601286
Cellular Component	GO:0032991	protein-containing complex	Gch1	IDA		Rat	PMID:8702680\|RGD:728623
Biological Process	GO:0051066	dihydrobiopterin metabolic process	Gch1	IDA		Rat	PMID:2557335\|RGD:2298653
Biological Process	GO:0051066	dihydrobiopterin metabolic process	Gch1	IDA		Rat	PMID:8486153\|RGD:2298654
Biological Process	GO:0051066	dihydrobiopterin metabolic process	Gch1	IDA		Rat	PMID:8702680\|RGD:728623
Biological Process	GO:0042416	dopamine biosynthetic process	GCH1	IDA		Human	PMID:16338639
Biological Process	GO:0045776	negative regulation of blood pressure	Gch1	IMP		Rat	PMID:12855421\|RGD:1601283
Biological Process	GO:0050884	neuromuscular process controlling posture	GCH1	IMP		Human	PMID:7874165
Biological Process	GO:0010460	positive regulation of heart rate	Gch1	IMP		Mouse	MGI:MGI:5629781\|PMID:25557619
Biological Process	GO:0051000	positive regulation of nitric-oxide synthase activity	GCH1	IDA		Human	PMID:12176133
Biological Process	GO:0051000	positive regulation of nitric-oxide synthase activity	GCH1	IDA		Human	PMID:15721862
Biological Process	GO:0051000	positive regulation of nitric-oxide synthase activity	GCH1	IMP		Human	PMID:17717598
Biological Process	GO:0051000	positive regulation of nitric-oxide synthase activity	GCH1	IMP		Human	PMID:19666465
Biological Process	GO:0065003	protein-containing complex assembly	Gch1	IDA		Rat	PMID:11818540\|RGD:2298660
Biological Process	GO:0065003	protein-containing complex assembly	Gch1	IDA		Rat	PMID:9685352\|RGD:2298656
Biological Process	GO:0042559	pteridine-containing compound biosynthetic process	GCH1	IDA		Human	PMID:15721862
Biological Process	GO:0042559	pteridine-containing compound biosynthetic process	GCH1	IDA		Human	PMID:2463916
Biological Process	GO:0042559	pteridine-containing compound biosynthetic process	GCH1	IDA		Human	PMID:3753653
Biological Process	GO:0008217	regulation of blood pressure	GCH1	IMP		Human	PMID:17717598
Biological Process	GO:0008217	regulation of blood pressure	Gch1	IMP	MGI:MGI:1856903	Mouse	PMID:15824199
Biological Process	GO:0014916	regulation of lung blood pressure	Gch1	IMP	MGI:MGI:1856903	Mouse	PMID:15824199
Biological Process	GO:2000121	regulation of removal of superoxide radicals	GCH1	IMP		Human	PMID:19666465
Biological Process	GO:0032496	response to lipopolysaccharide	GCH1	IDA		Human	PMID:7678411
Biological Process	GO:0032496	response to lipopolysaccharide	GCH1	IDA		Human	PMID:9445252
Biological Process	GO:0048265	response to pain	Gch1	IDA		Rat	PMID:17057711\|RGD:8554553
Biological Process	GO:0034612	response to tumor necrosis factor	GCH1	IDA		Human	PMID:9445252
Biological Process	GO:0034341	response to type II interferon	GCH1	IDA		Human	PMID:12607127
Biological Process	GO:0034341	response to type II interferon	GCH1	IDA		Human	PMID:7678411
Biological Process	GO:0034341	response to type II interferon	GCH1	IDA		Human	PMID:9445252
Biological Process	GO:0006729	tetrahydrobiopterin biosynthetic process	GCH1	IMP		Human	PMID:17101830
Biological Process	GO:0006729	tetrahydrobiopterin biosynthetic process	GCH1	IMP		Human	PMID:19666465
Biological Process	GO:0006729	tetrahydrobiopterin biosynthetic process	GCH1	IDA		Human	PMID:7678411
Biological Process	GO:0006729	tetrahydrobiopterin biosynthetic process	GCH1	IDA		Human	PMID:9445252
Biological Process	GO:0042311	vasodilation	Gch1	IMP		Rat	PMID:12855421\|RGD:1601283
Biological Process	GO:0050936	xanthophore differentiation	gch2	IMP	ZFIN:ZDB-GENO-200722-16	Zfish	PMID:30896066

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/23/2024 MGI 6.23

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.