Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes FTO
  • Mouse genes Fto
  • Rat genes Fto
  • Zfish genes fto
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Fto

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0043734	DNA-N1-methyladenine dioxygenase activity	FTO	IDA		Human	PMID:20376003
Molecular Function	GO:0043734	DNA-N1-methyladenine dioxygenase activity	Fto	IDA		Mouse	MGI:MGI:4430814|PMID:17991826
Molecular Function	GO:0008198	ferrous iron binding	FTO	IDA		Human	PMID:20376003
Molecular Function	GO:1990931	mRNA N6-methyladenosine dioxygenase activity	FTO	IDA		Human	PMID:25452335
Molecular Function	GO:1990931	mRNA N6-methyladenosine dioxygenase activity	FTO	IDA		Human	PMID:26457839
Molecular Function	GO:1990931	mRNA N6-methyladenosine dioxygenase activity	FTO	IMP		Human	PMID:26458103
Molecular Function	GO:1990931	mRNA N6-methyladenosine dioxygenase activity	FTO	IDA		Human	PMID:30197295
Molecular Function	GO:0035516	oxidative DNA demethylase activity	FTO	IDA		Human	PMID:18775698
Molecular Function	GO:0035516	oxidative DNA demethylase activity	FTO	IDA		Human	PMID:20376003
Molecular Function	GO:0035516	oxidative DNA demethylase activity	Fto	IDA		Mouse	MGI:MGI:3817348|PMID:18775698
Molecular Function	GO:0035515	oxidative RNA demethylase activity	FTO	IDA		Human	PMID:18775698
Molecular Function	GO:0035515	oxidative RNA demethylase activity	FTO	IDA		Human	PMID:22002720
Molecular Function	GO:0035515	oxidative RNA demethylase activity	FTO	IDA		Human	PMID:28002401
Molecular Function	GO:0035515	oxidative RNA demethylase activity	FTO	IDA		Human	PMID:30197295
Molecular Function	GO:0035515	oxidative RNA demethylase activity	Fto	IDA		Mouse	MGI:MGI:3817348|PMID:18775698
Molecular Function	GO:1990984	tRNA demethylase activity	FTO	IDA		Human	PMID:30197295
Cellular Component	GO:0005737	cytoplasm	FTO	IDA		Human	PMID:28002401
Cellular Component	GO:0005829	cytosol	FTO	IDA		Human	GO_REF:0000052
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	FTO	IDA		Human	GO_REF:0000052
Cellular Component	GO:0016607	nuclear speck	FTO	IDA		Human	PMID:22002720
Cellular Component	GO:0005634	nucleus	FTO	IDA		Human	PMID:26458103
Cellular Component	GO:0005634	nucleus	FTO	IDA		Human	PMID:28002401
Cellular Component	GO:0005634	nucleus	FTO	IDA		Human	PMID:30197295
Cellular Component	GO:0005634	nucleus	Fto	IDA		Mouse	MGI:MGI:4430814|PMID:17991826
Cellular Component	GO:0005634	nucleus	Fto	IDA		Mouse	MGI:MGI:3840763|PMID:19234441
Cellular Component	GO:0005886	plasma membrane	FTO	IDA		Human	GO_REF:0000052
Biological Process	GO:0060612	adipose tissue development	Fto	IMP		Mouse	MGI:MGI:3840763|PMID:19234441
Biological Process	GO:0043009	chordate embryonic development	fto	IMP	ZFIN:ZDB-MRPHLNO-140806-2	Zfish	PMID:24503721
Biological Process	GO:0043009	chordate embryonic development	fto	IMP	ZFIN:ZDB-MRPHLNO-140806-1	Zfish	PMID:24503721
Biological Process	GO:0060271	cilium assembly	fto	IMP	ZFIN:ZDB-MRPHLNO-140806-1	Zfish	PMID:24503721
Biological Process	GO:0006307	DNA dealkylation involved in DNA repair	FTO	IDA		Human	PMID:18775698
Biological Process	GO:0006307	DNA dealkylation involved in DNA repair	FTO	IDA		Human	PMID:20376003
Biological Process	GO:0006307	DNA dealkylation involved in DNA repair	Fto	IDA		Mouse	MGI:MGI:3817348|PMID:18775698
Biological Process	GO:0080111	DNA demethylation	FTO	IDA		Human	PMID:18775698
Biological Process	GO:0080111	DNA demethylation	Fto	IDA		Mouse	MGI:MGI:3817348|PMID:18775698
Biological Process	GO:0080111	DNA demethylation	Fto	IDA		Mouse	MGI:MGI:4430814|PMID:17991826
Biological Process	GO:0060972	left/right pattern formation	fto	IMP	ZFIN:ZDB-MRPHLNO-140806-1	Zfish	PMID:24503721
Biological Process	GO:0061157	mRNA destabilization	FTO	IDA		Human	PMID:28002401
Biological Process	GO:0061157	mRNA destabilization	FTO	IDA		Human	PMID:30197295
Biological Process	GO:0070989	oxidative demethylation	FTO	IDA		Human	PMID:18775698
Biological Process	GO:0070989	oxidative demethylation	Fto	IDA		Mouse	MGI:MGI:3817348|PMID:18775698
Biological Process	GO:0035552	oxidative single-stranded DNA demethylation	FTO	IDA		Human	PMID:18775698
Biological Process	GO:0035552	oxidative single-stranded DNA demethylation	FTO	IDA		Human	PMID:20376003
Biological Process	GO:0035552	oxidative single-stranded DNA demethylation	Fto	IDA		Mouse	MGI:MGI:3817348|PMID:18775698
Biological Process	GO:0035553	oxidative single-stranded RNA demethylation	FTO	IDA		Human	PMID:18775698
Biological Process	GO:0035553	oxidative single-stranded RNA demethylation	FTO	IDA		Human	PMID:22002720
Biological Process	GO:0035553	oxidative single-stranded RNA demethylation	FTO	IDA		Human	PMID:25452335
Biological Process	GO:0035553	oxidative single-stranded RNA demethylation	FTO	IDA		Human	PMID:26457839
Biological Process	GO:0035553	oxidative single-stranded RNA demethylation	FTO	IMP		Human	PMID:26458103
Biological Process	GO:0035553	oxidative single-stranded RNA demethylation	FTO	IDA		Human	PMID:28002401
Biological Process	GO:0035553	oxidative single-stranded RNA demethylation	FTO	IDA		Human	PMID:30197295
Biological Process	GO:0035553	oxidative single-stranded RNA demethylation	Fto	IDA		Mouse	MGI:MGI:3817348|PMID:18775698
Biological Process	GO:0090263	positive regulation of canonical Wnt signaling pathway	fto	IMP	ZFIN:ZDB-MRPHLNO-140806-1	Zfish	PMID:24503721
Biological Process	GO:0090335	regulation of brown fat cell differentiation	FTO	IMP		Human	PMID:26287746
Biological Process	GO:0010883	regulation of lipid storage	FTO	IMP		Human	PMID:26287746
Biological Process	GO:0010883	regulation of lipid storage	Fto	IMP		Mouse	MGI:MGI:3840763|PMID:19234441
Biological Process	GO:0040014	regulation of multicellular organism growth	Fto	IMP		Mouse	MGI:MGI:3840763|PMID:19234441
Biological Process	GO:0044065	regulation of respiratory system process	Fto	IMP		Mouse	MGI:MGI:3840763|PMID:19234441
Biological Process	GO:0070350	regulation of white fat cell proliferation	Fto	IMP		Mouse	MGI:MGI:3840763|PMID:19234441
Biological Process	GO:0042245	RNA repair	FTO	IDA		Human	PMID:18775698
Biological Process	GO:0042245	RNA repair	Fto	IDA		Mouse	MGI:MGI:3817348|PMID:18775698
Biological Process	GO:0001659	temperature homeostasis	Fto	IMP		Mouse	MGI:MGI:3840763|PMID:19234441

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern