Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes FREM2
  • Mouse genes Frem2
  • Rat genes Frem2
  • Zfish genes frem2a,frem2b,frem3
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Frem2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	FREM2	IPI	UniProtKB:Q5H8C1	Human	PMID:29688405
Molecular Function	GO:0005515	protein binding	Frem2	IPI	UniProtKB:Q80T14	Mouse	MGI:MGI:3654854|PMID:16880404
Cellular Component	GO:0005604	basement membrane	Frem2	IDA		Mouse	MGI:MGI:3697950|PMID:17251066
Cellular Component	GO:0005604	basement membrane	Frem2	IDA		Mouse	PMID:16880404
Cellular Component	GO:0005604	basement membrane	Frem2	IDA		Mouse	PMID:17596926
Cellular Component	GO:0062023	collagen-containing extracellular matrix	Frem2	HDA		Mouse	MGI:MGI:6201834|PMID:22159717
Cellular Component	GO:0070062	extracellular exosome	FREM2	HDA		Human	PMID:23533145
Biological Process	GO:0007155	cell adhesion	FREM2	IMP		Human	PMID:29688405
Biological Process	GO:0042733	embryonic digit morphogenesis	Frem2	IMP	MGI:MGI:3794302	Mouse	PMID:26234751
Biological Process	GO:0001654	eye development	FREM2	IMP		Human	PMID:29688405
Biological Process	GO:0001654	eye development	FREM2	IMP		Human	PMID:30802441
Biological Process	GO:0001654	eye development	Frem2	IMP		Mouse	MGI:MGI:6368066|PMID:30802441
Biological Process	GO:0001654	eye development	Frem2	IMP	MGI:MGI:3794302	Mouse	PMID:26234751
Biological Process	GO:0033333	fin development	frem2a	IMP		Zfish	PMID:9007245
Biological Process	GO:0033334	fin morphogenesis	frem2a	IMP	ZFIN:ZDB-GENO-100420-12	Zfish	PMID:20419147
Biological Process	GO:0007507	heart development	Frem2	IMP		Mouse	PMID:25807483
Biological Process	GO:0048839	inner ear development	Frem2	IDA		Mouse	PMID:21795542
Biological Process	GO:0001822	kidney development	Frem2	IMP	MGI:MGI:5429852	Mouse	PMID:27002738
Biological Process	GO:0002009	morphogenesis of an epithelium	Frem2	IMP	MGI:MGI:3578641	Mouse	PMID:15838507

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern