Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes FEM1A
  • Mouse genes Fem1a
  • Rat genes Fem1a
  • Zfish genes fem1a
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Fem1a

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0031867	EP4 subtype prostaglandin E2 receptor binding	FEM1A	IPI	UniProtKB:P35408	Human	PMID:16424369
Molecular Function	GO:0005515	protein binding	FEM1A	IPI	UniProtKB:A6NEM1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	FEM1A	IPI	UniProtKB:O14561	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	FEM1A	IPI	UniProtKB:P09110	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	FEM1A	IPI	UniProtKB:Q0VD86	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	FEM1A	IPI	UniProtKB:Q5VTT5-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	FEM1A	IPI	UniProtKB:Q8N543	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	FEM1A	IPI	UniProtKB:Q9BVG8-5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	FEM1A	IPI	UniProtKB:Q9NZC7-5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	FEM1A	IPI	UniProtKB:Q9UDY8-2	Human	PMID:32296183
Molecular Function	GO:1990756	ubiquitin ligase-substrate adaptor activity	FEM1A	IDA		Human	PMID:29779948
Molecular Function	GO:1990756	ubiquitin ligase-substrate adaptor activity	FEM1A	IDA		Human	PMID:33398168
Molecular Function	GO:1990756	ubiquitin ligase-substrate adaptor activity	FEM1A	IDA		Human	PMID:33398170
Cellular Component	GO:0031462	Cul2-RING ubiquitin ligase complex	FEM1A	IDA		Human	PMID:29779948
Cellular Component	GO:0005739	mitochondrion	FEM1A	IDA		Human	PMID:19406122
Cellular Component	GO:0005739	mitochondrion	Fem1a	IDA		Mouse	MGI:MGI:6695672|PMID:19406122
Biological Process	GO:0050728	negative regulation of inflammatory response	FEM1A	IDA		Human	PMID:16424369
Biological Process	GO:0050728	negative regulation of inflammatory response	Fem1a	IGI	MGI:MGI:104311	Mouse	PMID:18270204
Biological Process	GO:0043407	negative regulation of MAP kinase activity	Fem1a	IDA		Mouse	PMID:18270204
Biological Process	GO:0050729	positive regulation of inflammatory response	Fem1a	IMP		Mouse	MGI:MGI:6694450|PMID:27315781
Biological Process	GO:0140627	ubiquitin-dependent protein catabolic process via the C-end degron rule pathway	FEM1A	IDA		Human	PMID:29779948
Biological Process	GO:0140627	ubiquitin-dependent protein catabolic process via the C-end degron rule pathway	FEM1A	IDA		Human	PMID:33398168
Biological Process	GO:0140627	ubiquitin-dependent protein catabolic process via the C-end degron rule pathway	FEM1A	IDA		Human	PMID:33398170

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern