Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes FBXL22
  • Mouse genes Fbxl22
  • Rat genes Fbxl22
  • Zfish genes fbxl22
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Fbxl22

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	FBXL22	IPI	UniProtKB:P63208	Human	PMID:32296183
Molecular Function	GO:0061630	ubiquitin protein ligase activity	FBXL22	IDA		Human	PMID:22972877
Cellular Component	GO:0005829	cytosol	FBXL22	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005730	nucleolus	FBXL22	IDA		Human	GO_REF:0000052
Cellular Component	GO:0019005	SCF ubiquitin ligase complex	Fbxl22	IDA		Rat	PMID:22972877|RGD:10400868
Cellular Component	GO:0030018	Z disc	Fbxl22	IDA		Rat	PMID:22972877|RGD:10400868
Biological Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	FBXL22	IDA		Human	PMID:22972877
Biological Process	GO:0086004	regulation of cardiac muscle cell contraction	fbxl22	IMP	ZFIN:ZDB-MRPHLNO-140130-3	Zfish	PMID:22972877
Biological Process	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	fbxl22	IMP	ZFIN:ZDB-MRPHLNO-140130-3	Zfish	PMID:22972877

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern