Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes FBXL2
  • Mouse genes Fbxl2
  • Rat genes Fbxl2
  • Zfish genes fbxl2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Fbxl2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0036312	phosphatidylinositol 3-kinase regulatory subunit binding	FBXL2	IPI	UniProtKB:O00459	Human	PMID:23604317
Molecular Function	GO:0036312	phosphatidylinositol 3-kinase regulatory subunit binding	FBXL2	IPI	UniProtKB:P27986	Human	PMID:23604317
Molecular Function	GO:0005515	protein binding	FBXL2	IPI	UniProtKB:P26664	Human	PMID:15893726
Molecular Function	GO:0005515	protein binding	FBXL2	IPI	UniProtKB:Q9P035	Human	PMID:18160438
Molecular Function	GO:0005515	protein binding	FBXL2	IPI	UniProtKB:P63208	Human	PMID:19159283
Molecular Function	GO:0005515	protein binding	FBXL2	IPI	UniProtKB:P08238	Human	PMID:22939624
Molecular Function	GO:0005515	protein binding	FBXL2	IPI	UniProtKB:P08238	Human	PMID:25036637
Molecular Function	GO:0005515	protein binding	FBXL2	IPI	UniProtKB:P63208	Human	PMID:26790640
Molecular Function	GO:0005515	protein binding	FBXL2	IPI	UniProtKB:P63208	Human	PMID:27705803
Molecular Function	GO:0005515	protein binding	FBXL2	IPI	UniProtKB:P63208	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	FBXL2	IPI	UniProtKB:P48643	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Fbxl2	IPI	PR:P49586	Mouse	PMID:21343341
Molecular Function	GO:0019903	protein phosphatase binding	FBXL2	IPI	UniProtKB:Q12923	Human	PMID:23604317
Molecular Function	GO:1990756	ubiquitin ligase-substrate adaptor activity	FBXL2	IDA		Human	PMID:26037928
Molecular Function	GO:1990756	ubiquitin ligase-substrate adaptor activity	Fbxl2	IDA		Mouse	MGI:MGI:5488521|PMID:23542741
Cellular Component	GO:0016020	membrane	FBXL2	IDA		Human	PMID:15893726
Cellular Component	GO:0019005	SCF ubiquitin ligase complex	FBXL2	IDA		Human	PMID:23604317
Cellular Component	GO:0019005	SCF ubiquitin ligase complex	FBXL2	IDA		Human	PMID:26037928
Biological Process	GO:0044830	modulation by host of viral RNA genome replication	FBXL2	IMP		Human	PMID:15893726
Biological Process	GO:1900226	negative regulation of NLRP3 inflammasome complex assembly	FBXL2	IDA		Human	PMID:26037928
Biological Process	GO:0006513	protein monoubiquitination	Fbxl2	IGI	MGI:MGI:103575,MGI:MGI:1349658,MGI:MGI:1891829	Mouse	PMID:21343341
Biological Process	GO:0006513	protein monoubiquitination	Fbxl2	IMP		Mouse	PMID:21343341
Biological Process	GO:0016567	protein ubiquitination	FBXL2	IDA		Human	PMID:23604317
Biological Process	GO:0010506	regulation of autophagy	FBXL2	IMP		Human	PMID:23604317
Biological Process	GO:0050727	regulation of inflammatory response	Fbxl2	IDA		Mouse	MGI:MGI:5488521|PMID:23542741
Biological Process	GO:0014066	regulation of phosphatidylinositol 3-kinase signaling	FBXL2	IDA		Human	PMID:23604317
Biological Process	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	FBXL2	IDA		Human	PMID:23604317
Biological Process	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	FBXL2	IDA		Human	PMID:26037928
Biological Process	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	Fbxl2	IDA		Mouse	MGI:MGI:5488521|PMID:23542741
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	Fbxl2	IMP		Mouse	PMID:21343341

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern