Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ERN2
  • Mouse genes Ern2
  • Rat genes Ern2
  • Zfish genes ern2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ern2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005524	ATP binding	ERN2	IDA		Human	PMID:11175748
Molecular Function	GO:0004519	endonuclease activity	ERN2	IDA		Human	PMID:11175748
Molecular Function	GO:0000287	magnesium ion binding	ERN2	IDA		Human	PMID:11175748
Molecular Function	GO:0005515	protein binding	Ern2	IPI	UniProtKB:Q12933	Mouse	MGI:MGI:3777353|PMID:10650002
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ERN2	IDA		Human	PMID:11175748
Cellular Component	GO:0005829	cytosol	ERN2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005783	endoplasmic reticulum	ERN2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0044322	endoplasmic reticulum quality control compartment	Ern2	IDA		Mouse	MGI:MGI:6467680|PMID:17707796
Cellular Component	GO:1990604	IRE1-TRAF2-ASK1 complex	Ern2	IDA		Mouse	MGI:MGI:5616327|PMID:12050113
Biological Process	GO:0030263	apoptotic chromosome condensation	ERN2	IMP		Human	PMID:11175748
Biological Process	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	Ern2	IDA		Mouse	PMID:9755171
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	ERN2	IMP		Human	PMID:11175748
Biological Process	GO:0043507	positive regulation of JUN kinase activity	Ern2	IDA		Mouse	MGI:MGI:3777353|PMID:10650002
Biological Process	GO:0006468	protein phosphorylation	ERN2	IDA		Human	PMID:11175748
Biological Process	GO:0006355	regulation of DNA-templated transcription	Ern2	IDA		Mouse	MGI:MGI:1346198|PMID:9755171
Biological Process	GO:0034976	response to endoplasmic reticulum stress	Ern2	IDA		Mouse	MGI:MGI:3777353|PMID:10650002
Biological Process	GO:0034976	response to endoplasmic reticulum stress	Ern2	IMP	MGI:MGI:2677494	Mouse	PMID:11238559
Biological Process	GO:0016075	rRNA catabolic process	ERN2	IDA		Human	PMID:11175748

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern