Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes EPHA5
  • Mouse genes Epha5
  • Rat genes Epha5
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Epha5

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005003	ephrin receptor activity	Epha5	IDA		Rat	PMID:20824214|RGD:8554330
Molecular Function	GO:0005004	GPI-linked ephrin receptor activity	Epha5	IDA		Mouse	MGI:MGI:5294297|PMID:17448994
Molecular Function	GO:0019838	growth factor binding	Epha5	IPI	UniProtKB:P52797	Rat	PMID:22568954|RGD:40902966
Molecular Function	GO:0019838	growth factor binding	Epha5	IPI	UniProtKB:P52801	Rat	PMID:22568954|RGD:40902966
Molecular Function	GO:0005515	protein binding	EPHA5	IPI	UniProtKB:P29317	Human	PMID:35384245
Molecular Function	GO:0005515	protein binding	EPHA5	IPI	UniProtKB:P54760	Human	PMID:35384245
Molecular Function	GO:0005515	protein binding	Epha5	IPI	UniProtKB:P35546-2	Mouse	MGI:MGI:5307244|PMID:22304922
Molecular Function	GO:0005515	protein binding	Epha5	IPI	PR:P52801	Mouse	PMID:9883724
Molecular Function	GO:0005515	protein binding	Epha5	IPI	PR:O08543	Mouse	PMID:9883724
Molecular Function	GO:0005515	protein binding	Epha5	IPI	UniProtKB:P97605	Rat	PMID:20824214|RGD:8554330
Cellular Component	GO:0005912	adherens junction	Epha5	IDA		Mouse	PMID:23242526
Cellular Component	GO:0030424	axon	Epha5	IDA		Rat	PMID:7748564|RGD:728210
Cellular Component	GO:0071944	cell periphery	Epha5	IDA		Mouse	PMID:23242526
Cellular Component	GO:0030425	dendrite	EPHA5	IDA		Human	PMID:10375373
Cellular Component	GO:0030425	dendrite	EPHA5	IDA		Human	PMID:9191074
Cellular Component	GO:0009897	external side of plasma membrane	EPHA5	IDA		Human	PMID:10064801
Cellular Component	GO:0043025	neuronal cell body	EPHA5	IDA		Human	PMID:10375373
Cellular Component	GO:0048471	perinuclear region of cytoplasm	EPHA5	IDA		Human	PMID:10375373
Cellular Component	GO:0005886	plasma membrane	EPHA5	IDA		Human	PMID:10375373
Cellular Component	GO:0005886	plasma membrane	Epha5	IDA		Rat	PMID:7748564|RGD:728210
Cellular Component	GO:0005791	rough endoplasmic reticulum	EPHA5	IDA		Human	PMID:10375373
Biological Process	GO:0007411	axon guidance	Epha5	IDA		Mouse	MGI:MGI:2384261|PMID:12124402
Biological Process	GO:0019933	cAMP-mediated signaling	Epha5	IDA		Rat	PMID:20824214|RGD:8554330
Biological Process	GO:0071372	cellular response to follicle-stimulating hormone stimulus	Epha5	IDA		Mouse	PMID:23242526
Biological Process	GO:1904322	cellular response to forskolin	Epha5	IDA		Mouse	PMID:23242526
Biological Process	GO:0060997	dendritic spine morphogenesis	Epha5	IDA		Rat	PMID:20824214|RGD:8554330
Biological Process	GO:0048013	ephrin receptor signaling pathway	Epha5	IDA		Mouse	MGI:MGI:5294297|PMID:17448994
Biological Process	GO:0048013	ephrin receptor signaling pathway	Epha5	IDA		Rat	PMID:20824214|RGD:8554330
Biological Process	GO:0021766	hippocampus development	Epha5	IDA		Mouse	MGI:MGI:2384261|PMID:12124402
Biological Process	GO:0007162	negative regulation of cell adhesion	Epha5	IDA		Rat	PMID:23242526|RGD:11041026
Biological Process	GO:0048666	neuron development	EPHA5	IEP		Human	PMID:10375373
Biological Process	GO:0032793	positive regulation of CREB transcription factor activity	Epha5	IMP		Rat	PMID:20824214|RGD:8554330
Biological Process	GO:0032956	regulation of actin cytoskeleton organization	Epha5	IDA		Mouse	MGI:MGI:5294297|PMID:17448994
Biological Process	GO:0043087	regulation of GTPase activity	Epha5	IDA		Mouse	MGI:MGI:5294297|PMID:17448994
Biological Process	GO:0061178	regulation of insulin secretion involved in cellular response to glucose stimulus	Epha5	IDA		Mouse	MGI:MGI:5294297|PMID:17448994

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern