Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes EPHA1
  • Mouse genes Epha1
  • Rat genes Epha1
  • Zfish genes epha2a,epha2b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Epha1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005003	ephrin receptor activity	Epha1	IDA		Mouse	MGI:MGI:6467924|PMID:11519828
Molecular Function	GO:0001968	fibronectin binding	EPHA1	IDA		Human	PMID:18308734
Molecular Function	GO:0005515	protein binding	Epha1	IPI	UniProtKB:P52797	Mouse	MGI:MGI:6467924|PMID:11519828
Molecular Function	GO:0005515	protein binding	Epha1	IPI	UniProtKB:P20827	Mouse	MGI:MGI:6467924|PMID:11519828
Molecular Function	GO:0005515	protein binding	Epha1	IPI	UniProtKB:P52798	Mouse	MGI:MGI:6467924|PMID:11519828
Molecular Function	GO:0004672	protein kinase activity	EPHA1	IDA		Human	PMID:12775584
Molecular Function	GO:0019901	protein kinase binding	EPHA1	IPI	UniProtKB:Q05397	Human	PMID:19118217
Molecular Function	GO:0019901	protein kinase binding	EPHA1	IPI	UniProtKB:Q13418	Human	PMID:19118217
Molecular Function	GO:0005005	transmembrane-ephrin receptor activity	EPHA1	IDA		Human	PMID:19118217
Cellular Component	GO:0005886	plasma membrane	EPHA1	IDA		Human	PMID:19118217
Cellular Component	GO:0005886	plasma membrane	EPHA1	IDA		Human	PMID:16862074
Biological Process	GO:0090630	activation of GTPase activity	EPHA1	IDA		Human	PMID:19118217
Biological Process	GO:0007166	cell surface receptor signaling pathway	EPHA1	IDA		Human	PMID:19118217
Biological Process	GO:0030336	negative regulation of cell migration	EPHA1	IDA		Human	PMID:19118217
Biological Process	GO:0006469	negative regulation of protein kinase activity	EPHA1	IDA		Human	PMID:19118217
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	EPHA1	IDA		Human	PMID:12775584
Biological Process	GO:0045766	positive regulation of angiogenesis	EPHA1	IMP		Human	PMID:20043122
Biological Process	GO:0045766	positive regulation of angiogenesis	Epha1	IMP		Rat	PMID:18308734|RGD:39458028
Biological Process	GO:0030335	positive regulation of cell migration	EPHA1	IMP		Human	PMID:20043122
Biological Process	GO:0008284	positive regulation of cell population proliferation	EPHA1	IMP		Human	PMID:20043122
Biological Process	GO:0001954	positive regulation of cell-matrix adhesion	EPHA1	IDA		Human	PMID:19118217
Biological Process	GO:0051496	positive regulation of stress fiber assembly	Epha1	IDA		Mouse	MGI:MGI:5294306|PMID:12775584
Biological Process	GO:0046777	protein autophosphorylation	EPHA1	IDA		Human	PMID:19118217
Biological Process	GO:0043087	regulation of GTPase activity	EPHA1	IDA		Human	PMID:19118217
Biological Process	GO:0034446	substrate adhesion-dependent cell spreading	EPHA1	IDA		Human	PMID:19118217

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern