Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes DTL
  • Mouse genes Dtl
  • Rat genes Dtl
  • Zfish genes dtl
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Dtl

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	DTL	IPI	UniProtKB:Q13619,UniProtKB:Q16531	Human	PMID:16949367
Molecular Function	GO:0005515	protein binding	DTL	IPI	UniProtKB:Q16531	Human	PMID:16949367
Molecular Function	GO:0005515	protein binding	DTL	IPI	UniProtKB:Q16531	Human	PMID:17041588
Molecular Function	GO:0005515	protein binding	DTL	IPI	UniProtKB:P38936	Human	PMID:18794347
Molecular Function	GO:0005515	protein binding	DTL	IPI	UniProtKB:P38936	Human	PMID:23213251
Molecular Function	GO:0005515	protein binding	DTL	IPI	UniProtKB:Q16526	Human	PMID:26431207
Molecular Function	GO:0005515	protein binding	DTL	IPI	UniProtKB:Q6IQ49	Human	PMID:27906959
Molecular Function	GO:0005515	protein binding	DTL	IPI	UniProtKB:P40337-2	Human	PMID:32814053
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	DTL	IDA		Human	PMID:18794347
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	DTL	IDA		Human	PMID:20129063
Cellular Component	GO:0005813	centrosome	DTL	IDA		Human	PMID:17106265
Cellular Component	GO:0080008	Cul4-RING E3 ubiquitin ligase complex	DTL	IMP		Human	PMID:16949367
Cellular Component	GO:0031464	Cul4A-RING E3 ubiquitin ligase complex	DTL	IDA		Human	PMID:17085480
Cellular Component	GO:0031464	Cul4A-RING E3 ubiquitin ligase complex	DTL	IDA		Human	PMID:18794347
Cellular Component	GO:0031464	Cul4A-RING E3 ubiquitin ligase complex	DTL	IDA		Human	PMID:20129063
Cellular Component	GO:0031464	Cul4A-RING E3 ubiquitin ligase complex	DTL	IDA		Human	PMID:21628527
Cellular Component	GO:0031465	Cul4B-RING E3 ubiquitin ligase complex	DTL	IDA		Human	PMID:18794347
Cellular Component	GO:0005829	cytosol	DTL	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005730	nucleolus	DTL	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	DTL	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	DTL	IDA		Human	PMID:17106265
Cellular Component	GO:0005634	nucleus	DTL	IDA		Human	PMID:26431207
Biological Process	GO:0006974	DNA damage response	DTL	IMP		Human	PMID:16949367
Biological Process	GO:0006974	DNA damage response	DTL	IDA		Human	PMID:20129063
Biological Process	GO:0007095	mitotic G2 DNA damage checkpoint signaling	DTL	IMP		Human	PMID:17085480
Biological Process	GO:0007095	mitotic G2 DNA damage checkpoint signaling	dtl	IMP		Zfish	PMID:17085480|ZFIN:ZDB-PUB-061108-24
Biological Process	GO:0007095	mitotic G2 DNA damage checkpoint signaling	dtl	IMP	ZFIN:ZDB-GENO-020426-11	Zfish	PMID:17085480
Biological Process	GO:0007095	mitotic G2 DNA damage checkpoint signaling	dtl	IMP	ZFIN:ZDB-GENO-040220-3	Zfish	PMID:17085480
Biological Process	GO:0007095	mitotic G2 DNA damage checkpoint signaling	dtl	IMP	ZFIN:ZDB-MRPHLNO-070111-1	Zfish	PMID:17085480
Biological Process	GO:0010971	positive regulation of G2/M transition of mitotic cell cycle	DTL	IMP		Human	PMID:16949367
Biological Process	GO:0045732	positive regulation of protein catabolic process	DTL	IMP		Human	PMID:16949367
Biological Process	GO:0006513	protein monoubiquitination	DTL	IDA		Human	PMID:20129063
Biological Process	GO:0000209	protein polyubiquitination	DTL	IDA		Human	PMID:18794347
Biological Process	GO:0051726	regulation of cell cycle	DTL	IMP		Human	PMID:17085480
Biological Process	GO:0009411	response to UV	DTL	IDA		Human	PMID:18794347
Biological Process	GO:0019985	translesion synthesis	DTL	IDA		Human	PMID:20129063
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	DTL	IDA		Human	PMID:18794347
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	DTL	IMP		Human	PMID:26431207

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern