Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes DIS3
  • Mouse genes Dis3
  • Rat genes Dis3
  • Zfish genes dis3
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Dis3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0000175	3'-5'-RNA exonuclease activity	DIS3	IMP		Human	PMID:20531386
Molecular Function	GO:0004519	endonuclease activity	DIS3	IMP		Human	PMID:20531386
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	DIS3	IDA		Human	PMID:9562621
Molecular Function	GO:0005515	protein binding	DIS3	IPI	UniProtKB:Q01780	Human	PMID:15231747
Molecular Function	GO:0005515	protein binding	DIS3	IPI	UniProtKB:Q01780	Human	PMID:20531386
Molecular Function	GO:0005515	protein binding	DIS3	IPI	UniProtKB:Q9NQT5	Human	PMID:20531386
Molecular Function	GO:0005515	protein binding	DIS3	IPI	UniProtKB:Q9NQT5	Human	PMID:20531389
Molecular Function	GO:0005515	protein binding	DIS3	IPI	UniProtKB:Q01780	Human	PMID:21255825
Molecular Function	GO:0005515	protein binding	DIS3	IPI	UniProtKB:Q9NQT5	Human	PMID:21255825
Molecular Function	GO:0005515	protein binding	DIS3	IPI	UniProtKB:Q01780	Human	PMID:23756462
Molecular Function	GO:0005515	protein binding	DIS3	IPI	UniProtKB:Q14147	Human	PMID:25220460
Cellular Component	GO:0005829	cytosol	DIS3	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	DIS3	IDA		Human	PMID:20531386
Cellular Component	GO:0016020	membrane	DIS3	HDA		Human	PMID:19946888
Cellular Component	GO:0000176	nuclear exosome (RNase complex)	DIS3	IDA		Human	PMID:20531386
Cellular Component	GO:0005654	nucleoplasm	DIS3	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	DIS3	IDA		Human	PMID:20531389
Cellular Component	GO:0005634	nucleus	DIS3	IDA		Human	PMID:20531386
Biological Process	GO:0071034	CUT catabolic process	DIS3	IMP		Human	PMID:19056938
Biological Process	GO:0006401	RNA catabolic process	DIS3	IDA		Human	PMID:17174896
Biological Process	GO:0006396	RNA processing	DIS3	IDA		Human	PMID:17174896
Biological Process	GO:0016075	rRNA catabolic process	DIS3	IMP		Human	PMID:20368444

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern