Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes DHX58
  • Mouse genes Dhx58
  • Rat genes Dhx58
  • Zfish genes dhx58
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Dhx58

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0016887	ATP hydrolysis activity	DHX58	IMP		Human	PMID:19211564
Molecular Function	GO:0003725	double-stranded RNA binding	DHX58	IDA		Human	PMID:18411269
Molecular Function	GO:0003725	double-stranded RNA binding	Dhx58	IDA		Mouse	PMID:21703541
Molecular Function	GO:0005515	protein binding	DHX58	IPI	UniProtKB:O95786	Human	PMID:17190814
Molecular Function	GO:0005515	protein binding	DHX58	IPI	UniProtKB:P11207	Human	PMID:19403670
Molecular Function	GO:0005515	protein binding	DHX58	IPI	UniProtKB:P30927	Human	PMID:19403670
Molecular Function	GO:0005515	protein binding	DHX58	IPI	UniProtKB:Q9EMA9	Human	PMID:19403670
Molecular Function	GO:0005515	protein binding	DHX58	IPI	UniProtKB:Q8IY21	Human	PMID:21791617
Molecular Function	GO:0005515	protein binding	DHX58	IPI	UniProtKB:O15226	Human	PMID:21903422
Molecular Function	GO:0005515	protein binding	DHX58	IPI	UniProtKB:P19525	Human	PMID:21903422
Molecular Function	GO:0005515	protein binding	DHX58	IPI	UniProtKB:P56537	Human	PMID:21903422
Molecular Function	GO:0005515	protein binding	DHX58	IPI	UniProtKB:Q7L2E3	Human	PMID:21903422
Molecular Function	GO:0005515	protein binding	DHX58	IPI	UniProtKB:Q9NUL3	Human	PMID:21903422
Molecular Function	GO:0005515	protein binding	DHX58	IPI	UniProtKB:Q9UKV8	Human	PMID:21903422
Molecular Function	GO:0005515	protein binding	DHX58	IPI	UniProtKB:Q9UPY3	Human	PMID:21903422
Molecular Function	GO:0005515	protein binding	DHX58	IPI	UniProtKB:Q14671	Human	PMID:25340845
Molecular Function	GO:0005515	protein binding	DHX58	IPI	UniProtKB:Q8TB72	Human	PMID:25340845
Molecular Function	GO:0005515	protein binding	DHX58	IPI	UniProtKB:Q16666	Human	PMID:30833792
Molecular Function	GO:0003724	RNA helicase activity	DHX58	IMP		Human	PMID:19211564
Molecular Function	GO:0003727	single-stranded RNA binding	DHX58	IDA		Human	PMID:18411269
Molecular Function	GO:0008270	zinc ion binding	DHX58	IDA		Human	PMID:19278996
Cellular Component	GO:0005737	cytoplasm	Dhx58	IDA		Mouse	PMID:11735219
Biological Process	GO:0002753	cytosolic pattern recognition receptor signaling pathway	DHX58	IMP		Human	PMID:19211564
Biological Process	GO:0045824	negative regulation of innate immune response	DHX58	IDA		Human	PMID:21525357
Biological Process	GO:0045824	negative regulation of innate immune response	Dhx58	IMP		Mouse	MGI:MGI:5318004|PMID:21525357
Biological Process	GO:0039534	negative regulation of MDA-5 signaling pathway	DHX58	IMP		Human	PMID:21187438
Biological Process	GO:0039536	negative regulation of RIG-I signaling pathway	DHX58	IDA		Human	PMID:18411269
Biological Process	GO:0039536	negative regulation of RIG-I signaling pathway	DHX58	IMP		Human	PMID:21187438
Biological Process	GO:0039536	negative regulation of RIG-I signaling pathway	Dhx58	IMP		Mouse	MGI:MGI:3836702|PMID:17475874
Biological Process	GO:0032480	negative regulation of type I interferon production	DHX58	IDA		Human	PMID:21525357
Biological Process	GO:0032480	negative regulation of type I interferon production	Dhx58	IMP		Mouse	MGI:MGI:5318004|PMID:21525357
Biological Process	GO:1900245	positive regulation of MDA-5 signaling pathway	Dhx58	IMP		Mouse	MGI:MGI:4421606|PMID:20080593
Biological Process	GO:1900246	positive regulation of RIG-I signaling pathway	Dhx58	IMP		Mouse	MGI:MGI:4421606|PMID:20080593
Biological Process	GO:0032481	positive regulation of type I interferon production	Dhx58	IMP		Mouse	MGI:MGI:4421606|PMID:20080593
Biological Process	GO:0045088	regulation of innate immune response	DHX58	IDA		Human	PMID:18411269
Biological Process	GO:0009617	response to bacterium	Dhx58	IEP		Mouse	PMID:23012479
Biological Process	GO:0009615	response to virus	Dhx58	IMP		Mouse	MGI:MGI:4421606|PMID:20080593

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern