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Dhx58
Gene Detail
Symbol

Name
ID
Dhx58
DEXH (Asp-Glu-X-His) box polypeptide 58
MGI:1931560
Synonyms
B430001I08Rik, D11Lgp2e, LPG2
Feature Type
protein coding gene
Genetic Map
Chromosome 11
63.52 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr11:100694884-100704271 bp, - strand
From VEGA annotation of GRCm38

  9388 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:69371  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: DHX58
Protein SuperFamily: interferon-induced helicase C domain-containing protein 1
Gene Tree: Dhx58

Human
homologs
DHX58, DEXH (Asp-Glu-X-His) box polypeptide 58
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 79132
neXtProt AC: NX_Q96C10

Human Synonyms: D11LGP2, D11lgp2e, LGP2, RLR-3

Human Chr (Location): 17q21.2; chr17:42101404-42112733 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Targeted(10)
Genomic Mutations involving Dhx58 (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele exhibit increased susceptibility to EMCV infection and decreased susceptibility to VSV infection. Mice homozygous for a different knock-out allele exhibit increased susceptibility to WNV infection.
 
Interactions
Dhx58 interacts with 55 markers (Mir7-1, Mir17, Mir18, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (30 annotations)
Process defense response to virus, immune system process, ...
Component cytoplasm
Function ATP binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (43)    Tissues (29)    Images (13)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 43
cDNA source data(34)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase dhx58    NEW 
Molecular
reagents
All nucleic(35) cDNA(35)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000002055 (Evidence)
Ensembl Gene Model ENSMUSG00000017830 (Evidence)
Entrez Gene 80861 (Evidence)
UniGene 271830
DFCI TC1580288, TC1593374
DoTS DT.101372582, DT.522047, DT.99839061
NIA Mouse Gene Index U033431
EC 3.6.4.13
Consensus CDS Project CCDS25431.1
International Mouse Phenotyping Consortium Status Dhx58
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000002055 VEGA Gene Model | MGI Sequence Detail 9388 C57BL/6J ±  kb
transcript OTTMUST00000004170 VEGA | MGI Sequence Detail 2412 Not Applicable 
polypeptide OTTMUSP00000001994 VEGA | MGI Sequence Detail 678 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(84 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR021673 C-terminal domain of RIG-I
InterPro IPR001650 Helicase, C-terminal
InterPro IPR014001 Helicase, superfamily 1/2, ATP-binding domain
InterPro IPR006935 Helicase/UvrB domain
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000032742 ATP-dependent RNA helicase DHX58
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:206447 Widau RC, et al., RIG-I-like receptor LGP2 protects tumor cells from ionizing radiation. Proc Natl Acad Sci U S A. 2014 Jan 28;111(4):E484-91
All references(40)
Other
accession IDs
MGI:1925936

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory