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Dhx58 Gene Detail
Summary
  • Symbol
    Dhx58
  • Name
    DEXH (Asp-Glu-X-His) box polypeptide 58
  • Synonyms
    B430001I08Rik, D11Lgp2e, LPG2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1931560
    NCBI Gene: 80861
  • Gene Overview
    MyGene.info: DHX58
Location & Maps
more
  • Sequence Map
    Chr11:100694884-100704271 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      9388 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    DHX58, DEXH-box helicase 58
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DHX58, DEXH-box helicase 58
    Orthology source: HGNC, HomoloGene
  • Synonyms
    D11LGP2, D11lgp2e, LGP2, RLR-3
  • Links
    NCBI Gene ID: 79132
    neXtProt AC: NX_Q96C10

  • Chr Location
    17q21.2; chr17:42101404-42112733 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    21 phenotypes from 4 alleles in 3 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    10
  • Targeted
    10
  • Genomic Mutations
    1 involving Dhx58
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit increased susceptibility to EMCV infection and decreased susceptibility to VSV infection. Mice homozygous for a different knock-out allele exhibit increased susceptibility to WNV infection.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000002055 VEGA Gene Model | MGI Sequence Detail 9388 C57BL/6J ±  kb
transcript OTTMUST00000004170 VEGA | MGI Sequence Detail 2412 Not Applicable  
polypeptide OTTMUSP00000001994 VEGA | MGI Sequence Detail 678 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    84 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000032742 ATP-dependent RNA helicase DHX58
  • EC
  • InterPro Domains
    IPR021673 C-terminal domain of RIG-I
    IPR001650 Helicase, C-terminal
    IPR014001 Helicase superfamily 1/2, ATP-binding domain
    IPR006935 Helicase/UvrB, N-terminal
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
Molecular
Reagents
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  • All nucleic 35
    cDNA 35

    Microarray probesets 4
Other
Accession IDs
less
MGI:1925936
References
more
  • Summaries
    All 37
    Developmental Gene Expression 1
    Gene Ontology 8
    Phenotypes 15
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:206447 Widau RC, et al., RIG-I-like receptor LGP2 protects tumor cells from ionizing radiation. Proc Natl Acad Sci U S A. 2014 Jan 28;111(4):E484-91

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory