Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes DDC
  • Mouse genes Ddc
  • Rat genes Ddc
  • Zfish genes ddc
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ddc

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0036467	5-hydroxy-L-tryptophan decarboxylase activity	DDC	IDA		Human	PMID:16338639
Molecular Function	GO:0016597	amino acid binding	Ddc	IDA		Rat	PMID:10569946|RGD:4139897
Molecular Function	GO:0004058	aromatic-L-amino-acid decarboxylase activity	DDC	IDA		Human	PMID:16338639
Molecular Function	GO:0004058	aromatic-L-amino-acid decarboxylase activity	Ddc	IDA		Mouse	PMID:23863468
Molecular Function	GO:0004058	aromatic-L-amino-acid decarboxylase activity	Ddc	IDA		Rat	PMID:10569946|RGD:4139897
Molecular Function	GO:0004058	aromatic-L-amino-acid decarboxylase activity	Ddc	IDA		Rat	PMID:12047348|RGD:727571
Molecular Function	GO:0004058	aromatic-L-amino-acid decarboxylase activity	Ddc	IDA		Rat	PMID:12703659|RGD:4139893
Molecular Function	GO:0004058	aromatic-L-amino-acid decarboxylase activity	Ddc	IDA		Rat	PMID:3379830|RGD:4139900
Molecular Function	GO:0019899	enzyme binding	DDC	IPI	UniProtKB:P07101	Human	PMID:19703902
Molecular Function	GO:0036468	L-dopa decarboxylase activity	DDC	IDA		Human	PMID:19703902
Molecular Function	GO:0005515	protein binding	DDC	IPI	UniProtKB:P10275	Human	PMID:12864730
Molecular Function	GO:0005515	protein binding	DDC	IPI	UniProtKB:Q99497	Human	PMID:19703902
Molecular Function	GO:0005515	protein binding	Ddc	IPI	RGD:3729	Rat	PMID:16981894|RGD:5129109
Molecular Function	GO:0005515	protein binding	Ddc	IPI	RGD:3694	Rat	PMID:19903816|RGD:5128868
Molecular Function	GO:0019904	protein domain specific binding	Ddc	IPI	RGD:734009	Rat	PMID:19903816|RGD:5128868
Molecular Function	GO:0030170	pyridoxal phosphate binding	Ddc	IDA		Rat	PMID:8422386|RGD:4139896
Cellular Component	GO:0030424	axon	Ddc	IDA		Rat	PMID:19589383|RGD:5128876
Cellular Component	GO:0005737	cytoplasm	Ddc	IDA		Mouse	PMID:23010799
Cellular Component	GO:0005737	cytoplasm	Ddc	IDA		Rat	PMID:3379830|RGD:4139900
Cellular Component	GO:0070062	extracellular exosome	DDC	HDA		Human	PMID:19056867
Cellular Component	GO:0043025	neuronal cell body	Ddc	IDA		Rat	PMID:19589383|RGD:5128876
Cellular Component	GO:0008021	synaptic vesicle	Ddc	IDA		Rat	PMID:19903816|RGD:5128868
Biological Process	GO:0015842	aminergic neurotransmitter loading into synaptic vesicle	Ddc	IDA		Rat	PMID:19903816|RGD:5128868
Biological Process	GO:0007420	brain development	ddc	IMP	ZFIN:ZDB-MRPHLNO-131018-4	Zfish	PMID:23940784
Biological Process	GO:0071312	cellular response to alkaloid	Ddc	IEP		Rat	PMID:18696327|RGD:5129084
Biological Process	GO:0071363	cellular response to growth factor stimulus	Ddc	IEP		Rat	PMID:17306206|RGD:5129106
Biological Process	GO:0071466	cellular response to xenobiotic stimulus	Ddc	IEP		Rat	PMID:18602388|RGD:5129085
Biological Process	GO:0007623	circadian rhythm	Ddc	IEP		Rat	PMID:12047348|RGD:727571
Biological Process	GO:0042416	dopamine biosynthetic process	Ddc	IDA		Rat	PMID:12703659|RGD:4139893
Biological Process	GO:0033076	isoquinoline alkaloid metabolic process	Ddc	IEP		Rat	PMID:18305432|RGD:5129087
Biological Process	GO:0010259	multicellular organism aging	Ddc	IEP		Rat	PMID:17112516|RGD:5129108
Biological Process	GO:0052314	phytoalexin metabolic process	Ddc	IEP		Rat	PMID:19185027|RGD:5128879
Biological Process	GO:0046684	response to pyrethroid	Ddc	IEP		Rat	PMID:19017407|RGD:5129082
Biological Process	GO:0009636	response to toxic substance	Ddc	IDA		Mouse	PMID:7904615
Biological Process	GO:0042427	serotonin biosynthetic process	Ddc	IDA		Rat	PMID:10027744|RGD:5129182

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern