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Ddc
Gene Detail
 Symbol
Name
ID
Ddc
dopa decarboxylase
MGI:94876
Synonyms Aadc, aromatic L-amino acid decarboxylase
Feature Type protein coding gene
Genetic Map
Chromosome 11
7.09 cM, cytoband A1-A4
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr11:11814101-11898044 bp, - strand
From VEGA annotation of GRCm38

  83944 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:618  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: aromatic-L-amino-acid decarboxylase
Gene Tree: Ddc

Human
homologs
Human Homolog DDC, dopa decarboxylase (aromatic L-amino acid decarboxylase)
NCBI Gene ID 1644
neXtProt AC  NX_P20711
Human Synonyms  AADC
Human Chr (Location)  7p12.2; chr7:50458436-50565457 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human DDC
Mutations,
alleles, and
phenotypes
All mutations/alleles(100) : Gene trapped(97) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for one knock-out allele exhibit preweaning phenotype. Mice homozygous for a different knock-in allele exhibit partial prenatal lethality, decreased body size, postnatal growth retardation, hypoactivity, increased anxiety, tremors, decreased heart rate and decreased dopamine levels.
 
Human Diseases Modeled Using Mouse Ddc (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Ddc interacts with 95 markers (Mir18, Mir18b, Mir19a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process carboxylic acid metabolic process, catecholamine biosynthetic process, ...
Component axon, cytoplasm, ...
Function amino acid binding, aromatic-L-amino-acid decarboxylase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (35 records)
Data Summary: Results (157)    Tissues (116)    Images (33)
Theiler Stages: 13, 17, 20, 22, 24, 26, 27, 28
Assay TypeResults
Immunohistochemistry 12
RNA in situ 113
Northern blot 4
RT-PCR 28
cDNA source data(53)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(66) cDNA(58) Primer pair(7) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000005164 (Evidence)
Ensembl Gene ModelENSMUSG00000020182 (Evidence)
Entrez Gene13195 (Evidence)
UniGene12906
DFCITC1582321, TC1614602, TC1715766
DoTSDT.101165929, DT.101381772, DT.55205943, DT.97358235
NIA Mouse Gene IndexU032515
EC4.1.1.28
Consensus CDS ProjectCCDS24439.1
International Mouse Knockout Project StatusDdc
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005164 VEGA Gene Model | MGI Sequence Detail 83944 C57BL/6J ±  kb
transcript OTTMUST00000011540 VEGA | MGI Sequence Detail 1922 Not Applicable 
polypeptide OTTMUSP00000005369 VEGA | MGI Sequence Detail 480 Not Applicable 

For the selected sequences
All sequences(66) RefSeq(14) UniProt(5)
Polymorphisms RFLP(1) : SNPs within 2kb(370 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR010977 Aromatic-L-amino-acid decarboxylase
InterPro IPR021115 Pyridoxal-phosphate binding site
InterPro IPR002129 Pyridoxal phosphate-dependent decarboxylase
InterPro IPR015424 Pyridoxal phosphate-dependent transferase
InterPro IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1
InterPro IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2
Protein Ontology PR:000006342 aromatic-L-amino-acid decarboxylase
References (Earliest) J:1591 Bruneau G, et al., Mapping of the dopa decarboxylase gene to the 11A band of the murine genome. Biochem Biophys Res Commun. 1992 Jul 31;186(2):926-30
(Latest) J:204677 Zhang MZ, et al., Role of epoxyeicosatrienoic acids (EETs) in mediation of dopamine's effects in the kidney. Am J Physiol Renal Physiol. 2013 Dec 15;305(12):F1680-6
All references(81)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-8818

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory