Ddc
Gene Detail

Symbol Name ID

Ddc dopa decarboxylase MGI:94876

Synonyms

Aadc, aromatic L-amino acid decarboxylase

Feature Type

protein coding gene

Genetic Map

Chromosome 11

7.09 cM, cytoband A1-A4
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr11:11814101-11898044 bp, - strand From VEGA annotation of GRCm38   83944 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:618  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: aromatic-L-amino-acid decarboxylase
Gene Tree: Ddc

Human homologs

Human Homolog		DDC, dopa decarboxylase (aromatic L-amino acid decarboxylase)
NCBI Gene ID		1644
neXtProt AC		NX_P20711
Human Synonyms		AADC
Human Chr (Location)		7p12.2; chr7:50458436-50565457 (-)  GRCh38
Disease Associations		(1) Diseases Associated with Human DDC

Alleles and phenotypes

All alleles(100) : Gene trapped(97) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 

Mice homozygous for one knock-out allele exhibit preweaning phenotype. Mice homozygous for a different knock-in allele exhibit partial prenatal lethality, decreased body size, postnatal growth retardation, hypoactivity, increased anxiety, tremors, decreased heart rate and decreased dopamine levels.

 
Human Diseases Modeled Using Mouse Ddc (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (23 annotations)

Process	carboxylic acid metabolic process, catecholamine biosynthetic process, ...
Component	axon, cytoplasm, ...
Function	amino acid binding, aromatic-L-amino-acid decarboxylase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (35 records)

Data Summary: Results (157)    Tissues (114)    Images (33)
Theiler Stages: 13, 17, 20, 22, 24, 26, 28

Assay Type	Results
Immunohistochemistry	12
RNA in situ	113
Northern blot	4
RT-PCR	28

cDNA source data(53)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(66) cDNA(58) Primer pair(7) Other(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000005164 (Evidence)
Ensembl Gene Model	ENSMUSG00000020182 (Evidence)
Entrez Gene	13195 (Evidence)
UniGene	12906
DFCI	TC1582321, TC1614602, TC1715766
DoTS	DT.101165929, DT.101381772, DT.55205943, DT.97358235
NIA Mouse Gene Index	U032515
EC	4.1.1.28
Consensus CDS Project	CCDS24439.1
International Mouse Knockout Project Status	Ddc

Sequences

Length	Strain/Species
genomic	OTTMUSG00000005164	VEGA Gene Model | MGI Sequence Detail	83944	C57BL/6J
transcript	OTTMUST00000011540	VEGA | MGI Sequence Detail	1922	Not Applicable
polypeptide	OTTMUSP00000005369	VEGA | MGI Sequence Detail	480	Not Applicable

All sequences(66) RefSeq(14) UniProt(5)

Polymorphisms

RFLP(1) : SNPs within 2kb(370 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR010977	Aromatic-L-amino-acid decarboxylase
InterPro	IPR021115	Pyridoxal-phosphate binding site
InterPro	IPR002129	Pyridoxal phosphate-dependent decarboxylase
InterPro	IPR015424	Pyridoxal phosphate-dependent transferase
InterPro	IPR015421	Pyridoxal phosphate-dependent transferase, major region, subdomain 1
InterPro	IPR015422	Pyridoxal phosphate-dependent transferase, major region, subdomain 2
Protein Ontology	PR:000006342	aromatic-L-amino-acid decarboxylase

References

(Earliest) J:1591 Bruneau G, et al., Mapping of the dopa decarboxylase gene to the 11A band of the murine genome. Biochem Biophys Res Commun. 1992 Jul 31;186(2):926-30
(Latest) J:204677 Zhang MZ, et al., Role of epoxyeicosatrienoic acids (EETs) in mediation of dopamine's effects in the kidney. Am J Physiol Renal Physiol. 2013 Dec 15;305(12):F1680-6
All references(81)

Other accession IDs

MGD-MRK-8818