Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CYP51A1
  • Mouse genes Cyp51
  • Rat genes Cyp51
  • Zfish genes cyp51
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cyp51

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0020037	heme binding	CYP51A1	IDA		Human	PMID:20149798
Molecular Function	GO:0008398	sterol 14-demethylase activity	CYP51A1	IDA		Human	PMID:20149798
Molecular Function	GO:0008398	sterol 14-demethylase activity	Cyp51	IDA		Rat	PMID:7581240|RGD:2316902
Molecular Function	GO:0008398	sterol 14-demethylase activity	Cyp51	IDA		Rat	PMID:7665087|RGD:1298863
Molecular Function	GO:0008398	sterol 14-demethylase activity	cyp51	IDA		Zfish	PMID:24361620
Cellular Component	GO:0001669	acrosomal vesicle	Cyp51	IDA		Rat	PMID:10927636|RGD:41412165
Cellular Component	GO:0005737	cytoplasm	Cyp51	IDA		Rat	PMID:10927636|RGD:41412165
Cellular Component	GO:0005783	endoplasmic reticulum	CYP51A1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	Cyp51	IDA		Rat	PMID:7581240|RGD:2316902
Cellular Component	GO:0016020	membrane	CYP51A1	HDA		Human	PMID:19946888
Biological Process	GO:0033488	cholesterol biosynthetic process via 24,25-dihydrolanosterol	Cyp51	IDA		Rat	PMID:7581240|RGD:2316902
Biological Process	GO:1900222	negative regulation of amyloid-beta clearance	Cyp51	IMP		Mouse	MGI:MGI:6270905|PMID:20876579
Biological Process	GO:0042177	negative regulation of protein catabolic process	Cyp51	IMP		Mouse	MGI:MGI:6270905|PMID:20876579
Biological Process	GO:0050709	negative regulation of protein secretion	Cyp51	IMP		Mouse	MGI:MGI:6270905|PMID:20876579
Biological Process	GO:0060282	positive regulation of oocyte development	Cyp51	IMP		Rat	PMID:11133687|RGD:41412164
Biological Process	GO:0044752	response to human chorionic gonadotropin	Cyp51	IEP		Rat	PMID:11133687|RGD:41412164
Biological Process	GO:0032868	response to insulin	Cyp51	IEP		Rat	PMID:10876162|RGD:41412168
Biological Process	GO:0010288	response to lead ion	Cyp51	IEP		Rat	PMID:12111004|RGD:41412167
Biological Process	GO:0001878	response to yeast	cyp51	IDA		Zfish	PMID:23947337
Biological Process	GO:0007283	spermatogenesis	Cyp51	IEP		Rat	PMID:9564839|RGD:41412162
Biological Process	GO:0006694	steroid biosynthetic process	CYP51A1	IDA		Human	PMID:20149798

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern