Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CYP2A13,CYP2A6,CYP2A7
  • Mouse genes Cyp2a4
  • Rat genes Cyp2a3
  • Zfish genes cyp2y3
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cyp2a4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008389	coumarin 7-hydroxylase activity	CYP2A6	IDA		Human	PMID:16086027
Molecular Function	GO:0008389	coumarin 7-hydroxylase activity	CYP2A6	IDA		Human	PMID:19029318
Molecular Function	GO:0008389	coumarin 7-hydroxylase activity	CYP2A6	IDA		Human	PMID:19651758
Molecular Function	GO:0019899	enzyme binding	CYP2A6	IPI	UniProtKB:P00167	Human	PMID:15680923
Molecular Function	GO:0019899	enzyme binding	CYP2A6	IPI	UniProtKB:P00388	Human	PMID:15680923
Molecular Function	GO:0020037	heme binding	CYP2A6	IDA		Human	PMID:16086027
Molecular Function	GO:0020037	heme binding	CYP2A13	IDA		Human	PMID:17428784
Cellular Component	GO:0005881	cytoplasmic microtubule	CYP2A6	IDA		Human	PMID:23264731
Biological Process	GO:0046226	coumarin catabolic process	CYP2A6	IDA		Human	PMID:19029318
Biological Process	GO:0009804	coumarin metabolic process	CYP2A6	IDA		Human	PMID:19651758
Biological Process	GO:0035634	response to stilbenoid	Cyp2a4	IEP		Mouse	MGI:MGI:4943399|PMID:17086191
Biological Process	GO:0008202	steroid metabolic process	CYP2A6	IMP		Human	PMID:18356043
Biological Process	GO:0042178	xenobiotic catabolic process	CYP2A6	IDA		Human	PMID:15680923
Biological Process	GO:0006805	xenobiotic metabolic process	CYP2A6	IMP		Human	PMID:18356043
Biological Process	GO:0006805	xenobiotic metabolic process	CYP2A6	IDA		Human	PMID:19651758

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern